Montana State University

Department of Cell Biology & Neuroscience

Montana State University
P.O. Box 173148
Bozeman, MT 59717-3148

Tel: (406) 994-5120
Fax: (406) 994-7077
E-mail: cellbio.msu@gmail.com
Location: 510 Leon Johnson Hall

Department Chair

Frances Lefcort, Ph.D.

 

Facebook

BIOLOGY 422: Genes and Cancer

SYLLABUS

Course Instructor
Dr. Roger Bradley
520 Leon Johnson Hall
994-7680
rbradley@montana.edu

Class Goals:

Students will gain an understanding of cancer as a disease of aberrant genes, resulting in aberrant protein products. Combined mutations in several different genes in several different cellular pathways result in the cancer phenotype: increased mitosis, immortalization, escape from apoptosis, cell motility (metastasis) and the growth of new blood vessels (angiogenesis).  In addition, the student will gain an appreciation for some of the new treatments for cancer that specifically target the aberrant proteins that contribute to the above phenotypes.  Finally, it is my hope that this class will foster an interest in cancer research so that some of you will join the “war on cancer” and help move the field forward.

Suggested Text: The Biology of Cancer, Robert A. Weinberg

Course Prerequisite: BIOL 302.

Lecture Schedule

# Lecture Topic Text
1 Introduction, cancer incidence and mortality Chapter 2
2 What is cancer? Chapter 2
3 Techniques for studying genes involved in cancer Various
4 Tumor viruses Chapter 3
5 Oncogenes Chapter 4
6 Tumor Suppressor Genes Chapter 7
7 Multistep pathway of tumorigenesis Chapter 11
8 Cell signaling and tyrosine kinases Chapter 5
9 Ras, Map kinase and early response genes Chapter 6
10 Proteins that control the cell cycle Chapter 8
11 Cell Cycle and RB Chapter 8
  Exam #1: Lectures 1-11 Sign up for presentations  
12 p53 - your friend and executioner Chapter 9
13 p53 and apoptosis Chapter 9
14 Cell immortalization Chapter 10
15 Stem cells and cancer 11.5-.8, 12.1-.3
16 Tumor angiogenesis Chapter 13
17 Metastasis Chapter 14
18 Tumor immunology Chapter 15
19 Tumor immunology (continued) Chapter 15
20 Inflammation and cancer Chapter 11
  Exam #2: Lectures 12-20.  
21 Colon Cancer + Student presentation. Abstracts Due Chapter 7,11
22 Colon Cancer (continued) + Student presentation Chapter 7,11
23 Colon Cancer (continued) + Student presentations Chapter 7,11
24 Breast Cancer + Student presentations Chapter 16
25 Breast Cancer + Student presentations  
26 Breast Cancer (continued) + Student presentations Chapter 16
27 Targeted Therapies + Student presentations Chapter 12
28 Targeted Therapies - Dr. Jack Hensold, MD Chapter 12
29 Targeted Therapies - Dr. Jack Hensold, MD Chapter 12
30 Environmental carcinogens + Student presentations Various
31 Environmental carcinogens + Student presentations Various
32 Diet and cancer + Student presentations Various
  Exam #3: Lectures 21-32  
33 Student presentations  
34 Student presentations  
35 Student Presentations  
36 Student Presentations  
37 Student Presentations  
38 Student Presentations  
     
  FINAL EXAM  

Campus ToolsStudent E-MailDesire2LearnMy InfoIT ResourcesMy Passwords