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> Department of Cell Biology and Neuroscience
at Montana State University
Cell Biology and Neuroscience Faculty
Dr. Linda Hyman
Associate Professor
Director, Montana WWAMI Medical Education Program
Vice Provost, Division of Health Sciences
Affiliate Associate Professor, Department of Biochemistry,
University of Washington, School of Medicine
Assistant Dean, School of Medicine
University of Washington
Yeast Genetics, Cell Biology, Biochemistry
Our laboratory is currently investigating how cells adapt to the unique environment
encountered in space (ie: microgravity), using the model eukaryotic organism,
Saccharomyces cerevisiae.
Lab website: http://www.montana.edu/polyaaa/
Selected Publications
Purevdorj-Gage, B., Sheehan, K.B. and L. E. Hyman. 2006. Effects of Low-Shear Modeled
Microgravity on Cell Function, Gene Expression, and Phenotype in Saccharomyces cerevisiae.
Applied and Environmental Microbiology. 72: 4569-4575.
Purevdorj-Gage, B., Sheehan, K.B. and L. E. Hyman. 2006. The Role of FLO11 in Saccharomyces
cerevisiae Biofilm Development in Laboratory Based Flow-Cell System. In Press
Sheehan, K.B., Hoang, McInnerney, Purevdorj-Gage, B. and L. E. Hyman. 2006. Yeast Genomic
Expression Patterns in Response to Low-Shear Modeled Microgravity. In Press
Johanson, K., Hoang, T., Sheth, M. and L. E. Hyman. 2003. GRS1: A yeast tRNA synthetase with
a role in mRNA 3' end formation. J. Biol. Chem. 278:35923-30.
Johanson, K., Allen, P., Lewis, F., Cubano, L., Hyman, L. E. and T. Hammond. 2002.
Saccharomyces cerevisiae gene expression changes during rotating wall vessel suspension
culture , J. Appl. Physiol. 93: 2171-2180.
Hyman, L. E., Kwon, E., Ghosh, S., McGee, J., Chachulska, A., Jackson, T. and W. H.
Baricos. 2002. Binding to Elongin C inhibits degradation of interacting proteins in yeast.
J. Biol. Chem. 277: 15586-15591.
Jackson, T., Kwon, E., Chachulska, A. M. and L. E. Hyman. 2000. Novel roles for Elongin
C in yeast. BBA 1491:161-176.
Zhao, J. Hyman, L. E . and C. L. Moore. 1999. Formation of mRNA 3' ends in Eukaryotes:
mechanism, regulation and interrelationships with other steps in mRNA synthesis. Microbiol.
Mol. Biol. Reviews 63: 405-445.
Magrath, C. M. and L. E. Hyman. 1999. A mutation in GRS1, a glycyl-tRNA synthetase,
affects 3'-end formation in Saccharomyces cerevisiae . Genetics 152:129-141.
Magrath, C. M., Lund , K., Miller, C. and L. E. Hyman. 1998. Overlapping 3'-end formation
signals and ARS elements: tightly linked but functionally separable. Gene 222:69-75.
Chen, S. and L. E. Hyman. 1998. A specific RNA-protein interaction at yeast polyadenylation
efficiency elements. Nucl. Acids Res. 26:4965-4974.
Miller, C., Martinat, M. and L. E. Hyman. 1998. Assessment of aryl hydrocarbon receptor
complex interactions using pBEVY plasmids: Expression vectors with bi-directional promoters
for use in Saccharomyces cerevisiae. Nucl. Acids Res. 26: 3577-3583.
Education
State University of New York at Albany , Albany , NY Biology B.S. 1978
Brandeis University , Waltham , MA Biology M.S. 1984
Brandeis University , Waltham , MA Biology Ph.D. 1988
Tufts University , Boston , MA Biology Postdoctoral 1988- Fellow 1993
Appointments
Activities
NSF: Visiting Scientist and Program Director for Genetics, 2000-2001.
USDA: Chair, NSF/USDA Awardees Workshop: Microbial Genomes, 2003, Panel Manager,
Microbial Sequencing Program, 2002.
NASA: Invited Participant in workshop on biological experimentation on the
international space station, 2/2002.
NIH: Special Emphasis Review Panel: Non-mammalian organisms for cancer drug
discovery, 05/02 and 11/01.
Participation in the American Indian Research Opportunities (AIRO) program as
a mentor to Vania White, Little Big Horn College, MT, Summer 2004.
Participation in the NSF/NIH/HHMI Complex Biological Systems UE Program as a
mentor to Allie Maffit, Carroll College, Helena, MT, Summer 2004.
Steering committee: BRIN-INBRE Collaborative Program, Montana State University , 2004.
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