• Patients with inherited and acquired immune system deficiencies have increased susceptibility to opportunistic fungal infections, such as Pneumocystis and Cryptococcus.
• Progressive bone marrow failure can occur in chronic inflammatory diseases with or without immunodeficiency; however, the link between immune system regulation, fungal infection, and bone marrow failure is unclear.
• Our recent work suggests that type 1 interferons and B lymphocytes play a role in maintaining hematopoiesis.
• The goal of this project is to determine how hematopoiesis is maintained during fungal lung infections and the role of lymphocytes and type 1 interferons in this process.

Lung granulomas; Pneumocystis infection

Normal bone marrow containing red blood cells, white blood cells, and platelets