Department of Chemistry & Biochemistry, Montana State University
Speaker: Amanda Byer, doctoral student,
Department of Chemistry & Biochemistry,
Montana State University
Date: Thursday, November 9, 2017
Time: 3:10 PM
Place: Byker Auditorium, Chemistry & Biochemistry Building
Title: Metabolic Reprogramming of Human Macrophages upon Exposure to Pseudomonas aeruginosa Biofilms
A reception will follow the lecture.
Amanda Fuchs, a doctoral student in the Department of Chemistry and Biochemistry and recipient of a 2016 Kopriva Graduate Student Fellowship, will present "Metabolic Reprogramming of Human Macrophages upon Exposure to Pseudomonas aeruginosa Biofilms" as part of the College of Letters and Sciences's Kopriva Science Seminar Series.
Macrophages are innate immune cells which are abundantly present in all bodily tissues where they perform critical functions in monitoring tissues for foreign particles and microbes. Metabolic dysregulation of macrophages has been correlated to a number of chronic inflammatory conditions, including rheumatoid arthritis, type 2 diabetes and atherosclerosis. Aberrant behavior of macrophages has also been observed in chronic wounds that are commonly colonized by bacterial biofilms, microbial communities that are able to evade the immune system. Since macrophages are key mediators in the transition between inflammation and proliferation in wound healing, we hypothesize that the presence of biofilm contributes to metabolic dysregulation in macrophages. Utilizing nuclear magnetic resonance-based (NMR) metabolomics and fluorescence-activated cell sorting (FACS), Fuchs’s research investigates the immunophenotype and metabolism of macrophages to distinguish how these innate immune cells respond to Pseudomonas aeruginosa biofilms.
Fuchs' lecture is presented by the Kopriva Science Seminar Series, which is funded through an endowment created by Phil Kopriva, a 1957 microbiology graduate from MSU. Kopriva, who died in 2002, also created an endowment to fund the Kopriva Graduate Fellowship Program, which provides support and opportunities for graduate students in the College of Letters and Science, particularly in the biomedical sciences. The series features seminars by MSU graduate students, faculty members and guest speakers. For more information about this and other Kopriva lectures, please visit www.montana.edu/lettersandscience/kopriva.html.