Willy Vlautin

Speaker: Larry Overman, Distinguished Professor of Chemistry, University of California - Irvine

Date: Friday, April 21, 2017
Time: 3:10 PM
Place: Byker Auditorium, Chemistry & Biochemistry Building

Title: Using Carbon Radicals

Sponsoring department: Chemistry & Biochemistry

Summary: Our contemporary lifestyle would not be possible without products, ranging from fuels, clothing, pharmaceutical and agricultural products to electronic devices, that are produced by organic chemistry. Convergent synthesis strategies in which an organic molecule is prepared by a branched approach wherein two or more fragments are combined at a late stage are almost always preferred over a linear approach in which the overall yield of the target molecule is eroded by the efficiency of each successive step in the sequence. As a result, reactions that achieve the high-yielding union of polyfunctional fragments have particular importance in the preparation of structurally intricate organic molecules. This lecture will discuss the under-appreciated utility of bimolecular reactions of free radicals to couple structurally intricate fragments with a particular emphasis on the total synthesis of heterocyclic diterpenoid natural products.

About the speaker: Larry Overman is the Distinguished Professor of Chemistry at the University of California, Irvine. He has earned numerous awards for his contributions to the advancement of synthetic organic chemistry, including the following awards since 2000: Roger Adams Award in Organic Chemistry, American Chemical Society, 2015; Ryoji Noyori Prize, Society of Synthetic Organic Chemistry, Japan, 2015; UCI Medal, University of California, Irvine, 2011; American Chemical Society, Herbert C. Brown Award for Creative Research in Synthetic Methods, 2010; Tetrahedron Prize for Creativity in Organic Chemistry, 2008; The Nagoya Medal of Organic Chemistry, 2007; International Society of Heterocyclic Chemistry Senior Award, 2005; American Chemical Society Arthur C. Cope Award, 2003; UC Irvine Distinguished Faculty Lectureship Award for Research, 2002–2003; Yamada Prize, 2002; and the Japan Society for the Promotion of Science Fellowship, 2000.

Overman is a member of the United States National Academy of Sciences and the American Academy of Arts and Sciences. He received his B. A. from Earlham College in 1965 and he earned his Ph.D. in organic chemistry from the University of Wisconsin-Madison, under the direction of Dr. Howard Whitlock, in 1969.

Prior to joining the faculty at the University of California, Irvine, in 1971, he was an NIH postdoctoral fellow at Columbia University with Dr. Ronald Breslow.