Herpes Simplex Virus
|Morphology||HSV-1 and HSV-2 are members of the Herpesviridea family. Are double stranded DNA viruses enclosed within an icosahedral capsid.|
|Modes of Transmission||Direct contact with infected secretions or mucous membranes or skins with lesions|
|Signs and Symptoms||Cold sores: Mainly caused by HSV-1. Gingivostomatitis, fever, sore throat, mucosal edema, and painful lesions Genital herpes: Sexually transmitted disease mainly caused by HSV-2. Bilateral, painful, and extensive genital ulcers, which heal without scarring within 12 days.|
|Incubation Period||1 to 26 days.|
|Treatment||Antiviral drugs like acyclovir, foscarnet valacyclovir, famciclovir, and penciclovir.|
|Surveillance||Monitor for symptoms|
|MSU Requirements||Report any exposures.|
|Laboratory Acquired Infections (LAIs)||None.|
|Sources||Virus is shed from saliva, cervix, and urethra.|
|BSL2||For all procedures involving known or potentially infected cultures.|
|ABSL2||For all procedures utilizing infected animals.|
|Small||Notify others working in the lab. Remove and don new PPE. Cover area of the spill with absorbent material and add 10 % Bleach. Allow 30 minutes hour of contact time. After 30 minutes and then cleanup and dispose of materials.|
|Large||For assistance, contact MSU's Biosafety Officer: Ryan Bartlett, firstname.lastname@example.org, (406) 994-6733
or Safety and Risk Management (406-994- 2711).
Flush eyes, mouth or nose for 5 minutes at eyewash station.
Wash area with soap and water for 5 minutes.
Immediately report incident to supervisor, complete a first report of injury report, and submit to Safety and Risk Management.
During business hours: Bridger Occupational Health 3406 Laramie Drive. Weekdays 8am -6pm. Weekends 9am-5pm
After business hours: Bozeman Deaconess Hospital Emergency Room 915 Highland Blvd Bozeman, MT
|Disinfection||Susceptible to 10 % Bleach, and 70 % ethanol.|
|Inactivation||Inactivated by dry heat (1 hour at 160-170° C).|
|Survival Outside Host||
|Minimum PPE Requirements||At minimum, gloves, closed toed shoes, lab coat, and appropriate face and eye protection prior to working with Herpes Simplex Virus. Additional PPE may be required depending on lab specific SOPs.|