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	Hyman Laboratory
Yeast Genetics, Cell Biology, and Biochemistry
415 Leon Johnson Hall Montana State University Bozeman, MT 59717 406.994.5415

Home	Lab Personnel	Research	Contact Information	MSU	Division of Health Sciences	WWAMI

Linda E. Hyman Ph.D.
Curriculum Vitae Education State University of New York at Albany , Albany , NY Biology B.S. 1978 Brandeis University , Waltham , MA Biology M.S. 1984 Brandeis University , Waltham , MA Biology Ph.D. 1988 Tufts University , Boston , MA Biology Postdoctoral 1988- Fellow 1993 Appointments 2003-present Vice Provost for the Division of Health Sciences, Montana State University Director, Montana WWAMI Medical Education Program Associate Professor, Department of Cell Biology and Neuroscience, Montana State University Affiliate Associate Professor, Department of Biochemistry, University of Washington , School of Medicine Assistant Dean, University of Washington , School of Medicine 2000-2001 Visiting Scientist, National Science Foundation, Program, Director for Eukaryotic Genetics 2001 Associate Professor, Department of Biochemistry, Tulane University Medical School 2000 Adjunct Associate Professor, Human Genetics Program and Hayward Genetics Center 1993-2000 Assistant Professor, Department of Biochemistry, Tulane University Medical School 1988-1993 Postdoctoral Fellow, Tufts University School of Medicine, Department of Molecular Biology and Microbiology 1989-1992 Consultant, International Biotechnology Laboratory, Cambridge , MA 1984-1986 Associate Research Scientist, Integrated Genetics Inc., Framingham MA Publications Most Revelent • Purevdorj-Gage, B., Sheehan, K.B. and L. E. Hyman. 2006. Effects of Low-Shear Modeled Microgravity on Cell Function, Gene Expression, and Phenotype in Saccharomyces cerevisiae . Applied and Environmental Microbiology. 72: 4569-4575 • Purevdorj-Gage, B., Sheehan, K.B. and L. E. Hyman. 2006. The Role of FLO 11 in Saccharomyces cerevisiae Biofilm Development in Laboratory Based Flow-Cell System. In Press • Sheehan, K.B., Hoang, McInnerney, Purevdorj-Gage, B. and L. E. Hyman. 2006. Yeast Genomic Expression Patterns in Response to Low-Shear Modeled Microgravity. In Press • Johanson, K., Hoang, T., Sheth, M. and L. E. Hyman. 2003. GRS1: A yeast tRNA synthetase with a role in mRNA 3' end formation. J. Biol. Chem. 278:35923-30. • Zhao, J. Hyman, L. E . and C. L. Moore. 1999. Formation of mRNA 3' ends in Eukaryotes: mechanism, regulation and interrelationships with other steps in mRNA synthesis. Microbiol. Mol. Biol. Reviews 63: 405-445. • Magrath, C. M. and L. E. Hyman. 1999. A mutation in GRS1, a glycyl-tRNA synthetase, affects 3'-end formation in Saccharomyces cerevisiae . Genetics 152:129-141. • Magrath, C. M., Lund , K., Miller, C. and L. E. Hyman. 1998. Overlapping 3'-end formation signals and ARS elements: tightly linked but functionally separable. Gene 222:69-75. • Chen, S. and L. E. Hyman. 1998. A specific RNA -protein interaction at yeast polyadenylation efficiency elements. Nucl. Acids Res. 26:4965-4974. Other Significant • Johanson, K., Allen, P., Lewis, F., Cubano, L., Hyman, L. E. and T. Hammond. 2002. Saccharomyces cerevisiae gene expression changes during rotating wall vessel suspension culture , J. Appl. Physiol. 93: 2171-2180. • Hyman, L. E., Kwon, E., Ghosh, S., McGee, J., Chachulska, A., Jackson, T. and W. H. Baricos. 2002. Binding to Elongin C inhibits degradation of interacting proteins in yeast. J. Biol. Chem. 277: 15586-15591. • Jackson, T., Kwon, E., Chachulska, A. M. and L. E. Hyman. 2000. Novel roles for Elongin C in yeast. BBA 1491:161-176. • Miller, C., Martinat, M. and L. E. Hyman. 1998. Assessment of aryl hydrocarbon receptor complex interactions using pBEVY plasmids: Expression vectors with bi-directional promoters for use in Saccharomyces cerevisiae . Nucl. Acids Res. 26: 3577-3583. Synergistic Activities NSF: Visiting Scientist and Program Director for Genetics, 2000-2001 USDA: Chair, NSF/USDA Awardees Workshop: Microbial Genomes, 2003, Panel Manager, Microbial Sequencing Program, 2002 NASA: Invited Participant in workshop on biological experimentation on the international space station, 2/2002 NIH: Special Emphasis Review Panel: Non-mammalian organisms for cancer drug discovery, 05/02 and 11/01 Participation in the American Indian Research Opportunities (AIRO) program as a mentor to Vania White, Little Big Horn College, MT, Summer 2004 Participation in the NSF/NIH/HHMI Complex Biological Systems UE Program as a mentor to Allie Maffit, Carroll College, Helena, MT, Summer 2004 Steering committee: BRIN-INBRE Collaborative Program, Montana State University , 2004

State University of New York at Albany , Albany , NY Biology B.S. 1978
Brandeis University , Waltham , MA Biology M.S. 1984
Brandeis University , Waltham , MA Biology Ph.D. 1988
Tufts University , Boston , MA Biology Postdoctoral 1988- Fellow 1993

2003-present

Vice Provost for the Division of Health Sciences, Montana State University
Director, Montana WWAMI Medical Education Program
Associate Professor, Department of Cell Biology and Neuroscience, Montana State University
Affiliate Associate Professor, Department of Biochemistry, University of Washington , School of Medicine
Assistant Dean, University of Washington , School of Medicine

2000-2001

Visiting Scientist, National Science Foundation, Program, Director for Eukaryotic Genetics

2001

Associate Professor, Department of Biochemistry, Tulane University Medical School

2000

Adjunct Associate Professor, Human Genetics Program and Hayward Genetics Center

1993-2000

Assistant Professor, Department of Biochemistry, Tulane University Medical School

1988-1993

Postdoctoral Fellow, Tufts University School of Medicine, Department of Molecular Biology and Microbiology

1989-1992

Consultant, International Biotechnology Laboratory, Cambridge , MA

1984-1986

Associate Research Scientist, Integrated Genetics Inc., Framingham MA

• Purevdorj-Gage, B., Sheehan, K.B. and L. E. Hyman. 2006. Effects of Low-Shear Modeled Microgravity on Cell Function, Gene Expression, and Phenotype in Saccharomyces cerevisiae . Applied and Environmental Microbiology. 72: 4569-4575

• Purevdorj-Gage, B., Sheehan, K.B. and L. E. Hyman. 2006. The Role of FLO 11 in Saccharomyces cerevisiae Biofilm Development in Laboratory Based Flow-Cell System. In Press

• Sheehan, K.B., Hoang, McInnerney, Purevdorj-Gage, B. and L. E. Hyman. 2006. Yeast Genomic Expression Patterns in Response to Low-Shear Modeled Microgravity. In Press

• Johanson, K., Hoang, T., Sheth, M. and L. E. Hyman. 2003. GRS1: A yeast tRNA synthetase with a role in mRNA 3' end formation. J. Biol. Chem. 278:35923-30.

• Zhao, J. Hyman, L. E . and C. L. Moore. 1999. Formation of mRNA 3' ends in Eukaryotes: mechanism, regulation and interrelationships with other steps in mRNA synthesis. Microbiol. Mol. Biol. Reviews 63: 405-445.

• Magrath, C. M. and L. E. Hyman. 1999. A mutation in GRS1, a glycyl-tRNA synthetase, affects 3'-end formation in Saccharomyces cerevisiae . Genetics 152:129-141.

• Magrath, C. M., Lund , K., Miller, C. and L. E. Hyman. 1998. Overlapping 3'-end formation signals and ARS elements: tightly linked but functionally separable. Gene 222:69-75.

• Chen, S. and L. E. Hyman. 1998. A specific RNA -protein interaction at yeast polyadenylation efficiency elements. Nucl. Acids Res. 26:4965-4974.

• Johanson, K., Allen, P., Lewis, F., Cubano, L., Hyman, L. E. and T. Hammond. 2002. Saccharomyces cerevisiae gene expression changes during rotating wall vessel suspension culture , J. Appl. Physiol. 93: 2171-2180.

• Hyman, L. E., Kwon, E., Ghosh, S., McGee, J., Chachulska, A., Jackson, T. and W. H. Baricos. 2002. Binding to Elongin C inhibits degradation of interacting proteins in yeast. J. Biol. Chem. 277: 15586-15591.

• Jackson, T., Kwon, E., Chachulska, A. M. and L. E. Hyman. 2000. Novel roles for Elongin C in yeast. BBA 1491:161-176.

• Miller, C., Martinat, M. and L. E. Hyman. 1998. Assessment of aryl hydrocarbon receptor complex interactions using pBEVY plasmids: Expression vectors with bi-directional promoters for use in Saccharomyces cerevisiae . Nucl. Acids Res. 26: 3577-3583.

NSF: Visiting Scientist and Program Director for Genetics, 2000-2001
USDA: Chair, NSF/USDA Awardees Workshop: Microbial Genomes, 2003, Panel Manager, Microbial Sequencing Program, 2002
NASA: Invited Participant in workshop on biological experimentation on the international space station, 2/2002
NIH: Special Emphasis Review Panel: Non-mammalian organisms for cancer drug discovery, 05/02 and 11/01
Participation in the American Indian Research Opportunities (AIRO) program as a mentor to Vania White, Little Big Horn College, MT, Summer 2004
Participation in the NSF/NIH/HHMI Complex Biological Systems UE Program as a mentor to Allie Maffit, Carroll College, Helena, MT, Summer 2004
Steering committee: BRIN-INBRE Collaborative Program, Montana State University , 2004