Synthetic secoisolariciresinol diglucoside (LGM2605) inhibits Libby amphibole fiber-induced acute inflammation in mice.

Authors

Melpo Christofidou-Solomidou, Ralph A. Pietrofesa, Kyewon Park, Steven M. Albelda, Kinta M. Serve, Deborah E. Keil, Jean C. Pfau

Publication

Toxicology and Applied Pharmacology

Abstract

Background Exposure to the Libby amphibole (LA) asbestos-like fibers found in Libby, Montana, is associated with inflammatory responses in mice and humans, and an increased risk of developing mesothelioma, asbestosis, pleural disease, and systemic autoimmune disease. Flaxseed-derived secoisolariciresinol diglucoside (SDG) has anti-inflammatory, anti-fibrotic, and antioxidant properties. We have previously identified potent protective properties of SDG against crocidolite asbestos exposure modeled in mice. The current studies aimed to extend those findings by evaluating the immunomodulatory effects of synthetic SDG (LGM2605) on LA-exposed mice. Methods Male and female C57BL/6 mice were given LGM2605 via gavage initiated 3?days prior to and continued for 3?days after a single intraperitoneal dose of LA fibers (200??g) and evaluated on day 3 for inflammatory cell influx in the peritoneal cavity using flow cytometry. Results LA exposure induced a significant increase (p?

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