Evidence-Based Medicine for Student Health Services
Robert J. Flaherty, MD
Swingle Student Health Service
Montana State University
Bozeman, MT 59717
Human Papillomavirus/Warts
 
Etiology Monitoring
Epidemiology Prognosis
Diagnosis Prevention
Treatment Patient Education
General Information
 
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Specific Conditions/Diseases

 
  
 
Etiology
No evidence is cited. 
 
Epidemiology
No evidence is cited. 
 
Diagnosis
Clinical Diagnosis
Screening for HPV infection during the routine periodic health examination of asymptomatic women is not warranted.  Every patient with newly diagnosed condyloma of the vulva should be screened for other STDs (chlamydia) and should undergo a Pap test in order to rule out the presence of subclinical cervical and/or vaginal lesions. Colposcopy is not routinely indicated. Laboratory/X-ray Diagnosis
No evidence is cited.

 
Treatment 
Genital warts are treated best by local application of 10% or 25% podophyllin, 10% podophyllotoxin or 85 percent trichloracetic acid. Podophyllotoxin is applied by the patient twice daily for three days.

Double-freezing (freeze-thaw-freeze at same appointment) of is more effective than a single freeze-thaw cycle for plantar warts, but not for hand warts. More frequent (q 1 week) freezing of all hand and plantar warts leads to a quicker cure, but not a greater rate of cure. Mean number of treatments needed to cure = 5 (range 1-29). 
  • Caveats
    • Age group studied: Unknown
    • Type/size: RCTs of 300 and 225 patients
    • Population characteristics: Referred to dermatology practice
    • Outcome measure: Disappearance of wart
    • Keratolytic "wart paint" used in all patients concurrently and plantar warts pared before freezing
  • Citations
 
Monitoring
No evidence is cited.

Prognosis 
No evidence is cited. 
 
Prevention
No evidence is cited. 

Patient Education
The following patient education materials are consistent with the available evidence.
Rev. 9/19/00
 
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This Web site developed and maintained by Robert J. Flaherty, MD.
Comments, additions and corrections are encouraged.