• Johns Hopkins University, B.A., Biology, 1978
• Johns Hopkins University School of Medicine, Ph.D., Physiology, 1996

1996 – 1998, Postdoctoral Fellow, Johns Hopkins University School of Medicine, with Dr. Roger H. Reeves, Department of Physiology

1998 – 2006, Postdoctoral Fellow, National Human Genome Research Institute, with Dr. Robert L. Nussbaum, Genetic Disease Research Branch

2006 – present, Assistant Professor, McLaughlin Research Institute

 

• Mechanism of alpha-synuclein toxicity in Parkinson's disease more...
• Function of a-synuclein more...
• Modeling Parkinson's disease in mice more...

Cabin, D.E., D. Murphy, R.L.Nussbaum.  Axonal pathology precedes cell body damage in a mouse motor neuron synucleinopathy, submitted.

Cabin, D.E., and R.L. Nussbaum, Nuclear localization of a-synuclein in mouse, ms. in preparation.

Cabin, D.E., S. Gispert-Sanchez, D. Murphy, G. Auburger, R.R. Myers, R.L. Nussbaum, 2005.  Exacerbated synucleinopathy in mice expressing A53T SNCA on a Snca null background.  Neurobiol. of Aging 26(1):25-35.

Cabin D.E.*, Shimazu K.*, Murphy D., Cole N.B., Gottschalk W., McIlwain K.L,. Orrison B., Chen A., Ellis C.E., Paylor R., Lu B. Nussbaum R.L., 2002.  Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein. J Neurosci. 22(20):8797-807.
*These authors contributed equally.

Pletcher, M., T. Wiltshire, D.E. Cabin, M. Villanueva, and R.H. Reeves.  2001. Use of Comparative Physical and Sequence Mapping to Annotate Mouse Chromosome 16 and Human Chromosome 21.  Genomics 74: 45-54.

Touchman, J.W., A. Dehejia, O. Chiba-Falek, D.E. Cabin, B.M. Orrison, M.H. Polymeropolous, and R.L. Nussbaum.  2001. Human and Mouse Alpha-Synuclein Genes:  Comparative Genomic Sequence Analysis and Identification of a Novel Gene Regulatory Element.  Genome Research 11: 78-86.


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Laboratory Members

Dan Zou
Postdoctoral Fellow

MegAnne Casey
Research Assistant