George A. Carlson, Director

Education:

University of Pennsylvania, PA, A.B., Biochemistry, 1969
Tufts University, Boston, MA, Ph.D., Physiology, 1976
University of Alberta, Edmonton, Canada, Postdoctoral, Immunogenetics, 1975-1977

Professional Experience:

1970-1975: Predoctoral Research Fellow, Tufts University School of Medicine; supervisor, Dr. G. Terres
1975-1977: Leukemia Society Postdoctoral Fellow under Dr. T.G. Wegmann, Department of Immunology, Unversity of Alberta (studies on hybrid resistance and on immunological aspects of pregnancy
1977-1980: Assistant Professor of Immunology; University of Alberta
1980-1985: Associate Staff Scientist, The Jackson Laboratory, Bar Harbor, ME
1985-1988: Staff Scientist, The Jackson Laboratory, Bar Harbor, ME
1988-Present: Adjunct Professor of Microbiology; Montana State University, Bozeman, MT
1993-Present: Adjunct Professor of Biological Sciences/Pharm. Sci., University of Montana, Missoula, MT
1993-1997: Advisor/Consultant; Millennium Pharmaceuticals, Inc.,Cambridge, MA
1988-Present: Director, McLaughlin Research Institute, Great Falls, MT

The Prion Disease Database (PDDB) is a public database that supports the prion disease research community by collecting, integrating, and presenting data from public sources and collaborating laboratories. The PDDB was originally created by the Institute for Systems Biology and the McLaughlin Research Institute, which have researched prion disease using a systems biology approach.

Recent Publications:

de Calignon A, Fox LM, Pitstick R, Carlson GA, Bacskai BJ, Spires-Jones TL, Human BT. Caspase activation precedes and leads to tangles. Nature. 2010 March 31. (Abstract)
Watts JC, Huo H, Bai Y,Ehsani S, Jeon AH, Shi T, Daude N, Lau A, Young R, Xu L, Carlson GA, Williams D, Westaway D, Schmitt-Ulms G. Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones. PLoS Pathog. 2009 Oct; 5(10):e1000608. (Abstract)
Babij P, Roudier M, Graves T, Han CY, Chhoa M, Li CM, Juan T, Morony S, Grisanti M, Li X, Yu L, Dwyer D, Lloyd DJ, Bass MB, Richards WG, Ebeling C, Amato J, Carlson G. New variants in the Enpp1 and Ptpn6 genes cause low BMD, crystal-related arthropathy, and vascular calcification. J Bone Miner Res. 2009 Sep;24(9):1552-64.(Abstract)
Gehlenborg N, Hwang D, Lee IY, Yoo H, Baxter D, Petritis B, Pitstick R, Marzolf B, Dearmond SJ, Carlson GA, Hood L. The Prion Disease Database: a comprehensive transcriptome resource for systems biology research in prion diseases. Database (Oxford). 2009;2009:bap011. Epub 2009 Sep 17.(Abstract)
de Calignon A, Spires-Jones TL, Pitstick R, Carlson GA, Hyman BT.Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy. J Neuropathol Exp Neurol. 2009 Jul;68(7):757-61.(Abstract)
Hwang D, Lee IY, Yoo H, Gehlenborg N, Cho JH, Petritis B, Baxter D, Pitstick R, Young R, Spicer D, Price ND, Hohmann JG, Dearmond SJ, Carlson GA, Hood LE.A systems approach to prion disease.Mol Syst Biol. 2009;5:252. Epub 2009 Mar 24.(Abstract)
Juan T, Véniant MM, Helmering J, Babij P, Baker DM, Damore MA, Bass MB, Gyuris T, Chhoa M, Li CM, Ebeling C, Amato J, Carlson GA, Lloyd DJ. Identification of three loci affecting HDL-cholesterol levels in a screen for chemically induced recessive mutations in mice.J Lipid Res. 2009 Mar;50(3):534-45. (Abstract)
Park H, Staehling-Hampton K, Appleby MW, Brunkow ME, Habib T, Zhang Y, Ramsdell F, Liggitt HD, Freie B, Tsang M, Carlson G, Friend S, Frevert C, Iritani BM.A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic protein 1 in lymphopoiesis and innate immunityJ Exp Med. 2008 Nov 24;205(12):2899-913. Epub 2008 Nov 17.(Abstract)
Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubinstein E, Boucheix C, Yang X, Stanley P, Lisanti MP, Dwek RA, Rudd PM, Moskovitz J, Epstein CJ, Cruz TD, Kuziel WA, Maeda N, Sap J, Ashe KH, Carlson GA, Tesseur I, Wyss-Coray T, Mucke L, Weisgraber KH, Mahley RW, Cohen FE, Prusiner SB.Genes contributing to prion pathogenesis.
J Gen Virol. 2008 Jul;89(Pt 7):1777-88.(Abstract)
Kumar R, McClain D, Young R, Carlson GA. Cholesterol transporter ATP-binding cassette A1 (ABCA1) is elevated in prion disease and affects PrPC and PrPSc concentrations in cultured cells.J Gen Virol. 2008 Jun;89(Pt 6):1525-32.(Abstract)
Park L, Zhou P, Pitstick R, Capone C, Anrather J, Norris EH, Younkin L, Younkin S, Carlson G, McEwen BS, Iadecola C.Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein.Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1347-52. Epub 2008 Jan 17.(Abstract)
Spires-Jones TL, de Calignon A, Matsui T, Zehr C, Pitstick R, Wu HY, Osetek JD, Jones PB, Bacskai BJ, Feany MB, Carlson GA, Ashe KH, Lewis J, Hyman BT. In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons.J Neurosci. 2008 Jan 23;28(4):862-7.(Abstract)
Watts JC, Drisaldi B, Ng V, Yang J, Strome B, Horne P, Sy MS, Yoong L, Young R, Mastrangelo P, Bergeron C, Fraser PE, Carlson GA, Mount HT, Schmitt-Ulms G, Westaway D.The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections.EMBO J. 2007 Sep 5;26(17):4038-50. Epub 2007 Aug 16.(Abstract)
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