Square Butte
George A. Carlson, Ph.D.

Education:
  • University of Pennsylvania, PA, A.B., Biochemistry, 1969
  • Tufts University, Boston, MA, Ph.D., Physiology, 1976
  • University of Alberta, Edmonton, Canada, Postdoctoral, Immunogenetics, 1975-1977

Professional Experience:
  • 1970-1975: Predoctoral Research Fellow, Tufts University School of Medicine; supervisor, Dr. G. Terres
  • 1975-1977: Leukemia Society Postdoctoral Fellow under Dr. T.G. Wegmann, Department of Immunology, Unversity of Alberta (studies on hybrid resistance and on immunological aspects of pregnancy
  • 1977-1980: Assistant Professor of Immunology; University of Alberta
  • 1980-1985: Associate Staff Scientist, The Jackson Laboratory, Bar Harbor, ME
  • 1985-1988: Staff Scientist, The Jackson Laboratory, Bar Harbor, ME
  • 1988-Present: Adjunct Professor of Microbiology; Montana State University, Bozeman, MT
  • 1993-Present: Adjunct Professor of Biological Sciences/Pharm. Sci., University of Montana, Missoula, MT
  • 1993-1997: Advisor/Consultant; Millennium Pharmaceuticals, Inc.,Cambridge, MA
  • 1988-Present: Director, McLaughlin Research Institute, Great Falls, MT

Research Interests:
  • Functional Genomics of Prion Disease Susceptibility more...
  • Early Host Responses to Prion Infection: Development of in Vivo and in Vitro Assays more...
  • Genetic Dissection of Mouse Models for Alzheimer's Disease more...

Recent Publications:
  • Spires TL, Orne JD, SantaCruz K, Pitstick R, Carlson GA, Ashe KH, Hyman BT. Region-specific dissociation ofneuronal loss and neurofibrillary pathology in a mouse model of tauopathy. Am J Pathol. 2006;168:5:1598-607.
  • Giri RK, Young R, Pitstick R, DeArmond SD, Prusiner SB and Carlson GA. Prion infection of mouse neurospheres. Proc Natl Acad Sci USA. 2006; 103:3875-3880.
  • Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, HorneP, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, Rozmahel R, Fraser PE, St George-Hyslop P, Carlson GA, Westaway D. Dissociated phenotypes in presenilin transgenic mice define functionally distinct {gamma}-secretases. Proc Natl Acad Sci USA. 2005; 102:8972-7.
  • Park L, Anrather J, Zhou P, Frys K, Pitstick R, Younkin S, Carlson GA, IadecolaC. NADPH oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide. J Neurosci. 2005; 25:1769-77.
  • Clark AT, Goldowitz D, Takahashi JS, Vitaterna MH, Siepka SM, Peters LL, Frankel WN, Carlson GA,Rossant J, Nadeau JH, Justice MJ.Implementing large-scale ENU mutagenesis screens in North America. Genetica. 2004; 122:51-64.
  • Krezowski J, Knudson D, Ebeling C, Pistick R, Giri RK, Schenk D, Westaway D, Younkin L, Younkin SG, Ashe KH, Carlson GA. Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression. Hum Mol Genet. 2004. 13:1989-97
  • Li F, Calingasan NY, Yu F, Mauck WM, Toidze M, Almeida CG, Takahashi RH, Carlson GA, Flint Beal M, Lin MT, Gouras GK. Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice. J Neurochem. 2004. 89:1308-12
  • Park L, Anrather J, Forster C, Kazama K, Carlson GA, Iadecola C, AB-Induced Vascular Oxidative Stress and Attenuation of Functional Hyperemia in Mouse Somatosensory Cortex. J Cerebral Blood Flow & Metabolism 2004;24:334-342.

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Laboratory Members

Chris Ebeling
Senior Research Assistant
(Mutagenesis)

Rose Pitstick
Senior Research Assistant
(Alzheimer's Disease)

Richard Bennett, Ph.D.
Postdoctoral Fellow
(Prion & Alzheimer's Disease)

Rebecca Young
Research Assistant
(Prion Diseases)

Miranda Orr
Graduate Student
(Alzheimer's Disease)

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