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Education:
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- University of Pennsylvania, PA, A.B., Biochemistry, 1969
- Tufts University, Boston, MA, Ph.D., Physiology, 1976
- University of Alberta, Edmonton, Canada, Postdoctoral, Immunogenetics,
1975-1977
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Professional Experience: |
- 1970-1975: Predoctoral Research Fellow, Tufts University School
of Medicine; supervisor, Dr. G. Terres
- 1975-1977: Leukemia Society Postdoctoral Fellow under Dr. T.G.
Wegmann, Department of Immunology, Unversity of Alberta (studies
on hybrid resistance and on immunological aspects of pregnancy
- 1977-1980: Assistant Professor of Immunology; University of Alberta
- 1980-1985: Associate Staff Scientist, The Jackson Laboratory,
Bar Harbor, ME
- 1985-1988: Staff Scientist, The Jackson Laboratory, Bar Harbor,
ME
- 1988-Present: Adjunct Professor of Microbiology; Montana State
University, Bozeman, MT
- 1993-Present: Adjunct Professor of Biological Sciences/Pharm.
Sci., University of Montana, Missoula, MT
- 1993-1997: Advisor/Consultant; Millennium Pharmaceuticals, Inc.,Cambridge,
MA
- 1988-Present: Director, McLaughlin Research Institute, Great
Falls, MT
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Research Interests:
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- Functional Genomics of Prion Disease Susceptibility more...
- Early Host Responses to Prion Infection: Development of in Vivo
and in Vitro Assays more...
- Genetic Dissection of Mouse Models for Alzheimer's Disease more...
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Recent Publications:
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- Spires TL, Orne JD, SantaCruz K, Pitstick R, Carlson GA, Ashe KH, Hyman BT. Region-specific dissociation ofneuronal loss and neurofibrillary pathology in a mouse model of tauopathy. Am J Pathol. 2006;168:5:1598-607.
- Giri RK, Young R, Pitstick R, DeArmond SD, Prusiner SB and Carlson GA. Prion infection of mouse neurospheres. Proc Natl Acad Sci USA. 2006; 103:3875-3880.
- Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, HorneP, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, Rozmahel R, Fraser PE, St George-Hyslop P, Carlson GA, Westaway D. Dissociated phenotypes in presenilin transgenic mice define functionally distinct {gamma}-secretases. Proc Natl Acad Sci USA. 2005; 102:8972-7.
- Park L, Anrather J, Zhou P, Frys K, Pitstick R, Younkin S, Carlson GA, IadecolaC. NADPH oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide. J Neurosci. 2005; 25:1769-77.
- Clark AT, Goldowitz D, Takahashi JS, Vitaterna MH, Siepka SM, Peters LL, Frankel WN, Carlson GA,Rossant J, Nadeau JH, Justice MJ.Implementing large-scale ENU mutagenesis screens in North America. Genetica. 2004; 122:51-64.
- Krezowski J, Knudson D, Ebeling C, Pistick R, Giri RK, Schenk
D, Westaway D, Younkin L, Younkin SG, Ashe KH, Carlson GA.
Identification of loci determining susceptibility to the lethal
effects of amyloid precursor protein transgene overexpression.
Hum Mol Genet. 2004. 13:1989-97
- Li F, Calingasan NY, Yu F, Mauck WM, Toidze M, Almeida CG, Takahashi
RH, Carlson GA, Flint Beal M, Lin MT, Gouras GK. Increased plaque
burden in brains of APP mutant MnSOD heterozygous knockout mice.
J Neurochem. 2004. 89:1308-12
- Park L, Anrather J, Forster C, Kazama K, Carlson GA, Iadecola C, AB-Induced
Vascular Oxidative Stress and Attenuation of Functional Hyperemia
in Mouse Somatosensory Cortex. J Cerebral Blood Flow & Metabolism
2004;24:334-342.
More
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