Selected Publications for George A. Carlson, Ph.D.

Spires TL, Orne JD, SantaCruz K, Pitstick R, Carlson GA, Ashe KH, Hyman BT. Region-specific dissociation ofneuronal loss and neurofibrillary pathology in a mouse model of tauopathy. Am J Pathol. 2006;168:5:1598-607.(Abstract)

Giri RK, Young R, Pitstick R, DeArmond SD, Prusiner SB and Carlson GA. Prion infection of mouse neurospheres. Proc Natl Acad Sci USA. 2006; 103:3875-3880.(Abstract)

Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, HorneP, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, Rozmahel R, Fraser PE, St George-Hyslop P, Carlson GA, Westaway D. Dissociated phenotypes in presenilin transgenic mice define functionally distinct {gamma}-secretases. Proc Natl Acad Sci USA. 2005; 102:8972-7.(Abstract)

Park L, Anrather J, Zhou P, Frys K, Pitstick R, Younkin S, Carlson GA, IadecolaC. NADPH oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide. J Neurosci. 2005; 25:1769-77.(Abstract)

Clark AT, Goldowitz D, Takahashi JS, Vitaterna MH, Siepka SM, Peters LL, Frankel WN, Carlson GA,Rossant J, Nadeau JH, Justice MJ.Implementing large-scale ENU mutagenesis screens in North America. Genetica. 2004; 122:51-64.(Abstract)

Krezowski J, Knudson D, Ebeling C, Pistick R, Giri RK, Schenk D, Westaway D, Younkin L, Younkin SG, Ashe KH, Carlson GA. Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression. Hum Mol Genet. 2004. 13:1989-97(Abstract)

Li F, Calingasan NY, Yu F, Mauck WM, Toidze M, Almeida CG, Takahashi RH, Carlson GA, Flint Beal M, Lin MT, Gouras GK. Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice. J Neurochem. 2004. 89:1308-12(Abstract)

Park L, Anrather J, Forster C, Kazama K, Carlson GA, Iadecola C, AB-Induced Vascular Oxidative Stress and Attenuation of Functional Hyperemia in Mouse Somatosensory Cortex. J Cerebral Blood Flow & Metabolism 2004;24:334-342.

Carlson GA. A welcoming environment for amyloid plaques. Nat Neurosci. 2003 Apr:4:328-30.

Carlson, G.A., Chapter 6 Gene Mapping to Gene Targeting: Application of Mouse Genetics to Human Disease pp.81-90. The Molecular & Genetic Basis of Neurologic and Psychiatric Disease. Edition 3, 2003 Edited by Rosenberg, Roger N., Prusiner, Stanley B., DiMauro, Salvatore.

Phinney AL, Drisaldi B, Schmidt SD, Lugowski S, Coronado V, Liang Y, Horne P, Yang J, Sekoulidis J, Coomaraswamy J, Chishti MA, Cox DW, Mathews PM, Nixon RA, Carlson GA, St George-Hyslop P, Westaway D. In vivo reduction of amyloid-beta by a mutant copper transporter. Proc Natl Acad Sci. 2003;100:14193-8.

Rosenberg RN, Prusiner SB, DiMauro S, Barchi R, Nestler EJ, …Carlson GA, The Molecular and Genetic Basis of Neurologic and Psychiatric Disease Third Edition.Elsevier 2003:81-89.

Westaway D, Carlson GA, Mammalian prion proteins: enigma, variation and vaccination. Trends in Biochemical Science:2002 June;27:301-7. (Abstract)

Westerman MA, Cooper-Blacketer D, Mariash A, Kotilinek L, Kawarabayashi T, Younkin LH, Carlson GA,Younkin SG, Ashe KH. The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. J Neurosci. 2002 22:1858-67. (Abstract)

Niwa K, Kazama K, Younkin L, Younkin SG, Carlson GA, Iadecola C.Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein.Am J Physiol Heart Circ Physiol. 2002 Jul;283:H315-23.

Carlson GA, Postexposure prophylaxis against transmissible spongiform encephalopathies: CpG oligodeoxynucleotides in mice.(Commentary) Lancet. 2002 20;360:184.

Niwa K, Kazama K, Younkin L, Younkin SG, Carlson GA, Iadecola C.Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein.Am J Physiol Heart Circ Physiol. 2002;283:H315-23.

Westaway D, Carlson GA, Mammalian prion proteins: enigma, variation and vaccination. Trends in Biochemical Science: 2002 June;27:301-7.

Niwa K, Kazama K, Younkin L, Younkin SG, Carlson GA, Iadecola C.Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein.Am J Physiol Heart Circ Physiol. 2002 Jul;283:H315-23.

Westerman MA, Cooper-Blacketer D, Mariash A, Kotilinek L, Kawarabayashi T, Younkin LH, Carlson GA, Younkin SG, Ashe KH. The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. J Neurosci. 2002 22:1858-67.

Niwa K, Kazama K, Younkin SG, Carlson GA, Iadecola C.Alterations in Cerebral Blood Flow and Glucose Utilization in Mice Overexpressing the Amyloid Precursor Protein.Neurobiol Dis. 2002 Feb; 9:61-68.

Niwa K, Porter VA, Kazama K, Cornfield D, Carlson GA, Iadecola C.A beta-peptides enhance vasoconstriction in cerebral circulation.Am J Physiol Heart Circ Physiol. 2001 Dec;281:H2417-24.

Wilson SM, Householder DB, Coppola V, Tessarollo L, Fritzsch B, Lee EC, Goss D, Carlson GA, Copeland NG, Jenkins NA. Mutations in Cdh23 Cause Nonsyndromic Hearing Loss in waltzer Mice.Genomics. 2001 Jun 1;74:228-33.

Chishti MA, Yang DS, Janus C, Phinney AL, Horne P, Pearson J, Strome R, Zuker N, Loukides J, French J, Turner S, Lozza G, Grilli M, Kunicki S, Morissette C, Paquette J, Gervais F, Bergeron C, Fraser PE, Carlson GA, George-Hyslop PS, Westaway D. Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J Biol Chem. 2001 Jun 15;276:21562-70.

Niwa K, Younkin L, Ebeling C, Turner SK, Westaway D, Younkin S, Ashe KH, Carlson GA, Iadecola C. Abeta 1-40- related reduction in functional hyperemia in mouse neocortex during somatosensory activation. Proc Natl Acad Sci U S A. 2000 15:9735-40.

Brewster, J.L., S.L. Martin, J. Toms, D. Goss, K. Wang, K. Zachrone, A. Davis, G. Carlson, L. Hood and J.D. Coffin Deletion of Dad1 in mice induces an apoptosis-associated embryonic death. Genesis 2000 26:271-278.

Janus C, D'Amelio S, Amitay O, Chishti MA, Strome R, Fraser P, Carlson GA, Roder JC, St George-Hyslop P, Westaway D. Spatial learning in transgenic mice expressing human presenilin 1 (PS1) transgenes. Neurobiol Aging.2000, 21:541-9.

Stephenson DA, Chiotti K, Ebeling C, Groth D, DeArmond SJ, Prusiner SB, Carlson GA. Quantitative trait loci affecting prion incubation time in mice. Genomics 2000, 69:47-53.

Niwa K, Carlson GA, Iadecola C. Exogenous Aß1-40 reproduced cerebrovascular alterations resulting from APP overexpression in mice. J Cereb Blood Flow Metab 2000,Dec. 20 157:91659-68.

Van Uden E, Carlson GA St. George-Hyslop P, Westaway D, Orlando R, Mallory M, Rockenstein E, Masliah E. Aberrant Presenilin-1 expression downregulates LDL receptor-related protein (LRP): Is LRP central to Alzheimer’s Disease Pathogenesis? Mol Cell Neurosci 1999,14:129-140.

Moore RC, Lee IY, Silverman GL, Harrison PM, Strome R, Heinrich C, Karunaratne A, Pasternak SH, Chishti MA, Liang Y, Mastrangelo P, Wang K, Smit AF, Katamine S, Carlson GA, Cohen FE, Prusiner SB, Melton DW, Tremblay P, Hood LE, Westaway D. Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel. J Mol Biol. 1999,292:797-817.

Prusiner SB, Scott MR, DeArmond SJ, Carlson GA. Transmission and replication of prions. In Prion Biology and Diseases, Cold Spring Harbor Laboratory Press, 1999, pp 142-190.

Nagle DL, McGrail SH, Vitale J, Woolf EA, Dussault BJ Jr, DiRocco L, Holmgren L, Montagno J, Bork P Huszar D, Fairchild-Huntress V, Ge P, Keilty J, Ebeling C, Baldini L, Gilchrist J, Burn P, Carlson GA, Moore KJ. The mahogany protein is a receptor involved in suppression of obesity. Nature.1999,398:148-52.

Iadecola C, Zhang F, Eckman C, Turner SK, Fischer E, Younkin S, Borchelt DR, Hsiao KK, Carlson GA. SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein. Nature Neurosci 1999,2:157-161.

Iadecola C, Hsiao KK, Niwa K, Carlson GA. Amyloid precursor protein, cerebrovascular regulation and cerebral ischemic injury: insights from transgenic mouse models. In Pharmacology of Cerebral Ischemia, J Kriegelstein (Ed), Scientific Publishers, Stuttgart, 1998, pp 227-236.

Carlson GA. Proof of the primacy of prion protein. Nature Genetics 1998, 18:94-95.

Markel P, Shu P, Ebeling C, Carlson GA, Nagle D, Smutko J, Moore KJ. Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains. Nature Genetics 1997, 17:280-284.

Carlson GA, Borchelt DR, Dake A, Turner S, Danielson V, Coffin JD, Eckman C, Meiners J, Nilsen SP, Younkin SG, Hsiao KK. Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice. Human Mol Genet 1997, 6:1951-1959.

Chishti MA, Strome R, Carlson GA, Westaway D. Syrian hamster prion protein (PrPC) is expressed in photoreceptor cells of the adult retina. Neurosci Lett 1997, 234: 11-14.

Yehiely F, Bamborough P, Da Costa M, Perry BJ, Thinakaran G, Cohen FE, Carlson GA, Prusiner SB. Identification of candidate proteins binding to prion protein. Neurobiol Disease 1997, 3:339-355.

Carlson GA, Banks S, Lund D, Reichert C, Groth D, Torchia M, Dearmond SJ, Prusiner SB. Failure to transmit disease from gray tremor mutant mice. J Virol 1997, 71:2342-2345.

Citron M, Westaway D, Xia W, Carlson G, Diehl T, Levesque G, Johnson-Wood, K, Lee M, Seubert P, Davis A, Kolodenko D, Motter R, Sherrington R, Perry B, Yao H, Strome R, Liebergurg I, Rommens J, Kim S, Schenk D, Fraser P, St. George-Hyslop P, Selkoe DJ. Mutant presenilins of Alzheimer’s Disease increase production of 42-residue amyloid ß-protein in both transfected cells and transgenic mice. Nature Medicine 1997, 3: 67-72.

Misumi DJ, Nagle DL, McGrail SH, Dussault BJ, Smutko JS, Chen H, Charlat O, Duyk GM, Ebeling C, Baldini L, Carlson GA, Moore KJ. The physical and genetic map surrounding the Lyst gene on mouse chromosome 13. Genomics 1997, 40: 147-150.

Kleyn PW, Fan W, Kovats SG, Lee JJ, Pulido JC, Wu Y, Berkemeier LR,Misumi DJ, Holmgren L, Charlat O, Woolf EA, Tayber O, Brody T, Shu P, Hawkins F, Kennedy B, Baldini L, Ebeling C, Alperin GD, Deeds J,Lakey ND, Culpepper J, Chen H, Glücksmann-Kuis MA, Carlson GA, Duyk GM, Moore, KJ. Identification and characterization of the mouse obesity gene tubby : A member of a novel gene family. Cell 1996; 85:281-290.

Carlson GA. Prion Strains. Curr. Topics Microbiol, 1996; 207:35-48.

Westaway D, Carlson GA, Prusiner SB. On Safari with PrP: Prion Diseases of Animals. Trends in Microbiol 1995; 3:141-147.

Hsiao KK, Borchelt DR, Olson K, Johannsdottir R, Kitt C, Yunis W, Xu S,Eckman C, Younkin S, Price D, Iadecola C, Clark HB, Carlson GA. Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins. Neuron 1995; 15:1203-1218.

Westaway D, Cooper C, Turner S, Da Costa M, Carlson GA, Prusiner SB.Structure and polymorphism of the mouse prion protein gene. Proc Natl Acad Sci (USA) 1994; 91:6418-6422.

Carlson G, Ebeling C, Yang S-L, Telling G, Torchia M, Groth D, Westaway D, DeArmond SJ, Prusiner SB. Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice. Proc Natl Acad Sci (USA) 1994; 91:5690-5694.

Carlson GA, DeArmond SJ, Torchia M, Westaway D, Prusiner SB. Genetics of prion diseases and prion diversity in mice. Phil. Transactions Royal Soc. (B) 1994; 343:363-369.

Westaway D, DeArmond SJ, Cayetano-Canlas J, Groth D, Foster D, Yang S-L, Torchia M, Carlson GA, Prusiner SB. Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins. Cell 1994; 76:117-129.

Turner SK, Miller CL, Wettstein PJ, Hasenkrug KJ, Stimpfling JH, Carlson GA. Meiotic recombination within the H-2K-H-2D interval: characterization of a panel of congenic mice, including 12 new strains, using DNAmarkers. Immunogenetics 1993; 38:332-340.

Carlson GA, Ebeling C, Torchia M, Westaway D, Prusiner SB. Delimiting the location of the scrapie prion incubation time gene on chromosome 2 of the mouse.Genetics 1993; 133:979-988.

Carlson GA, Westaway D, Prusiner SB. The genetics of prion susceptibility in the mouse. In: Prion Diseases of Humans and Animals. (SB Prusiner, J Collinge, J Powell, B Anderton, eds.) Ellis-Harwood, London 1992; pp. 509-523.

Yamaguchi F, Richards S-J, Beyreuther K, Salbaum M, Carlson GA, Dunnett SB. Transgenic mice for the amyloid precursor protein 695 isoform show spatial memory impairment. Neuroreport 1991;2:781-784.

Henson V, Palmer L, Banks S, Nadeau JH, Carlson GA. Loss of heterozygosity and mitotic linkage maps in the mouse. Proc Natl Acad Sci (USA) 1991;88:6486-6490.

Westaway D, Mirenda CA, Foster D, Zebarjadian Y, Scott M, Torchia M, Yang S-L, Serban H, DeArmond SJ, Ebeling C, Prusiner SB, Carlson GA. Paradoxical shortening of scrapie incubation times by expression of prion protein transgenes derived from long incubation time mice. Neuron 1991;7:59-68.

Carlson GA, Hsiao K, Oesch B, Westaway D, Prusiner SB. Genetics of Prion InfectionsTrendsin Genetics 1991; 7:61-65.

Carlson GA. Genetics of Prion Diversity and Host Susceptibility. Curr Microbiol Immunol 1991;172:153-164.

Prusiner SB, Scott M, Foster D, Pank-M, Groth D, Mirenda C, Torchia M, Yang S-L, Serban D, Carlson GA, Hoppe PC, Westaway D, DeArmond SJ. Transgenic studies implicate interactions between homologous PrP isoforms in scrapie prion replication. Cell 1990; 63:673-686.

Roths JB, Marshall JD, Allen RD, Carlson GA, Sidman CL. Spontaneous Pneumocystis carinii pneumonia in immunodeficient mutant scidmice:natural history and pathobiology. Amer. J. Path. 1990; 136:1173-1186.

Scott M, Foster D, Mirenda C, Serban D, Coufal F, Wächli M, Torchia M, Groth D, Carlson GA, DeArmond SJ, Westaway D, Prusiner SB. Transgenic mice expressing hamster prion protein exhibit scrapie incubation times and amyloid plaques characteristic of hamsters. Cell 1989; 59:847-857.

Carlson GA, Westaway D, DeArmond SJ, Peterson-Torchia M, Prusiner SB. Primary structure of prion protein may modify scrapie isolate properties. Proc Natl Acad Sci (USA) 1989; 86:7475-7479.

Westaway D, Carlson GA, Prusiner SB. Unraveling prion diseases through molecular genetics. Trends in Neurosciences 1989;12:221-227.

Carlson GA, Goodman PA, Lovett M, Taylor BA, Marshall ST, Peterson-Torchia M, Westaway D, Prusiner SB. Genetics and Polymorphism of the mouse prion gene complex: The control of scrapie incubation period. Mol Cell Biol 1988; 8:5528-5540.

Harrison DE, Lerner C, Hoppe PC, Carlson GA, Alling D. Large numbers of primitive stem cells are active simultaneously in aggregated embryo chimeric mice. Blood 1987; 69:773-777.

Carlson GA. Fifty years of H-2 research. Immunology Today 1987; 8:317-319.

Westaway D, Goodman PA, Mirenda CA, McKinley MP, Carlson GA, Prusiner SB.Distinct prion proteins in short and long scrapie incubation period mice. Cell 1987; 51:651-662.

Carlson GA, Kingsbury DT, Goodman PA, Coleman S, Marshall ST, DeArmond S, Westaway D, Prusiner SB. Linkage of prion protein and scrapie incubation time genes. Cell 1986; 46:503-11.

Carlson GA, Marshall ST, Kiesch A. Early events in natural resistance to bone marrow transplantation: use of radiolabeled bone marrowcells.Transplantation 1986;41:688-94.