Montana State University

Biotechnologies

Technologies Available for Licensing:

Lab on a chip for large-scale, real-time monitoring of metabolites in living systems (BB-2014-MEC)

Contact: Gary Bloomer, 406-994-7483

A Metabolite Extraction Chip - a device for extracting small molecules from biologically relevant fluids using a microfluidic based circuit directly coupled to a mass spectrometer. 

Thiosulfonate Switch Technique - a three step protocol for detection of S-nitrosylated proteins (GPA-2014-TST)

Contact: Gary Bloomer, 406-994-7483

Thiosulfonate switch technique: a new three step protocol for SNO detection in aqueous medium that traps protein S-nitrosothiols as mixed disulfides bearing a fluorescent probe at pH 4.0. 

Brighter Fluorescent Proteins for Monitoring Cellular Function in Research Organisms (SRS-2013-BRIGHT)

Contact: Nick Zelver, 406-994-7706

Standard fluorescent reporter proteins can be improved to emit significantly brighter fluorescence by inserting multiple fluorescent proteins into cells of model research organisms such as mice, worms, bacteria, zebrafish and flies.  MSU researchers demonstrated improved fluorescence in a research model fruit fly, Drosophila using two commercially available fluorescent reporter proteins, green fluorescent protein (GFP) and mCherry fluorescent proteins.  By cloning the six fluorescent proteins in the fly, they obtained a fluorescence that could easily be seen with the naked eye.  

Osteoarthritis Mouse Model for Non-Invasive, In-Vivo Study of Cartilage (JRK-2013-CBRM)

Contact: Gary Bloomer, 406-994-7483

A novel, transgenic mouse which expresses firefly luciferase under the inducible control of cartilage-specific cre recombinase targeted to the aggrecan gene. Applications in OA, RA, and Fracture Healing.

CRISPR-Based Technnology for Robust, Reversible Control of Multiple Genes without Off-Target Fallout (WBA-2012-CRISPR)

Contact: Gary Bloomer, 406-994-7483

The MSU CRISPR technology has the potential to lock on to the target genes to enable robust, specific programming of genes - switching off and on multiple genes to control genetic pathways responsible for serious dieases or capable of producing a variety of products including drugs, foods, high-value crops, and biofuels.

Novel Dyes for Proteomic Research, Drug Development and Diagnostics (DEA-2013-DYES)

Contact: Gary Bloomer, 406-994-7483

Researchers at Montana State University have developed optical labeling molecules - dyes - that posess increased detection sensitivity. These water-soluble Zwitterionic dyes also enable recovery of intact proteins and allow for versatile, high speed, multiplex analysis for proteomics.

Patents:
US 7,833,799
US 8,197,758
US 8,197,759

Publications:
Proteomic analysis of Sulfolobus solfataricus during Sulfolobus Turreted Icosahedral Virus infection
Proteomic and Systems Biologys Analysis of Monocytes Exposed to Securinine, a GABAA Receptor Antagonist and Immune Adjuvant

Trimodal Handheld Probe Based on Raman Spectroscopy and Confocal Imaging for Cancer Detection (DD-2008-PROBE)

Jointly developed with Vanderbilt University (link to VU website above).

Contact: Nick Zelver, 406-994-7706

A single handheld device for combined confocal imaging and confocal Raman spectroscopy as well as gross spatial imaging as a clinical diagnostic tool for cancer detection in humans, with a specific emphasis on the skin. 

Enhanced Properties of Bread Dough (MJM-2012-GLUD)

Contact: Gary Bloomer, 406-994-7483

Finding: New mutations for the Dx5 and Dy10 subunit genes in wheat which enable enhanced dough handling characteristics including mix time, elasticity, and extensibility.

  • Potential Applications:
    Easier handling in production process, lower imact on mixing machinery
  • Large size bread loafs
  • Improved pizza crusts, biscuits, artisan breads
  • Enhanced Properties of Bread Dough

Sample Concentrator (AR-2012-TRAP)

Contact: Gary Bloomer, 406-994-7483

An instrument and process for achieving high sample concentrations with high flow rate and lower incidence of fouling.

  • Applications:
    Pathogen detection in food, water, pharmaceutical process, industrial fluids, fuels, and other aqueous environments.
  • Can be used as a real-time, in-line, continuous monitor.
  • Sample Concentrator

Novel Agents to Enhance Tolerance to an Immunogen (PDW-2006-TOLE)

Contact: Nick Zelver, 406-994-7706

A new apprach to developing highly potent, antigen-specific agents, called "tolerizing agents", uses a mucosal targeting ligand fused to a specific antigen to induce host unresponsiveness solely to that antigen while avoiding global immune suppression.

Quaternary Ammonium Complex Provides Superior Broad Spectrum Antimicrobial Activity (CMJ-2005-CARB)

Contact: Nick Zelver, 406-994-7706

Binding biocide to soluble dendrimers targets and disrupts the cell wall providing a new approach to controlling household, industrial, and medical microorganisms.

Enhanced Innate Resistance to Infections (JMA-2006-TLRS)

Contact: Nick Zelver, 406-994-7706

Natural, non-toxic compounds trigger innate immunity to bacterial, viral, fungal, or parasitic infection.

Mouse Monoclonal Antibodies

Contact: Nick Zelver, 406-994-7706

Anti-gp91phox, Anti-p22phox and Anti- CAP-18