Technologies Available for Licensing:
Biological drug or probiotic food to treat autoimmune diseases with no immunosuppression and minimal immunogenicity (PDW-2012)
Contact: Nick Zelver, 406-994-7706
A broad-spectrum biological therapeutic that can be administered orally, nasally, or sublingually to treat autoimmune disorders without immunosuppression, a common therapy that suppresses beneficial immunity. The therapeutic can also be integrated into fermented diary products such as developing a novel probiotic yogurt that blocks autoimmune responses.
Novel Dyes for Proteomic Research, Drug Development and Diagnostics (DEA-2013-DYES)
Contact: Gary Bloomer, 406-994-7483
Researchers at Montana State University have developed optical labeling molecules - dyes - that posess increased detection sensitivity. These water-soluble Zwitterionic dyes also enable recovery of intact proteins and allow for versatile, high speed, multiplex analysis for proteomics.
Patents:
US 7,833,799
US 8,197,758
US 8,197,759Publications:
Proteomic analysis of Sulfolobus solfataricus during Sulfolobus Turreted Icosahedral Virus infection
Proteomic and Systems Biologys Analysis of Monocytes Exposed to Securinine, a GABAA Receptor Antagonist and Immune Adjuvant
Trimodal Handheld Probe Based on Raman Spectroscopy and Confocal Imaging for Cancer Detection (DD-2008-PROBE)
Jointly developed with Vanderbilt University (link to VU website above).
Contact: Nick Zelver, 406-994-7706
A single handheld device for combined confocal imaging and confocal Raman spectroscopy as well as gross spatial imaging as a clinical diagnostic tool for cancer detection in humans, with a specific emphasis on the skin.
- Handheld Scanning Confocal Raman BIOMEDICAL OPTICS Paper
- MSU News DD Skin Cancer
- Skin Care Detection Patent 8,300,220
Enhanced Properties of Bread Dough (MJM-2012-GLUD)
Contact: Gary Bloomer, 406-994-7483
Finding: New mutations for the Dx5 and Dy10 subunit genes in wheat which enable enhanced dough handling characteristics including mix time, elasticity, and extensibility.
- Potential Applications:
Easier handling in production process, lower imact on mixing machinery - Large size bread loafs
- Improved pizza crusts, biscuits, artisan breads
- Enhanced Properties of Bread Dough
Sample Concentrator (AR-2012-TRAP)
Contact: Gary Bloomer, 406-994-7483
An instrument and process for achieving high sample concentrations with high flow rate and lower incidence of fouling.
- Applications:
Pathogen detection in food, water, pharmaceutical process, industrial fluids, fuels, and other aqueous environments. - Can be used as a real-time, in-line, continuous monitor.
- Sample Concentrator
Rotavirus Vaccine Adjuvant (HME-2012-GRA)
Contact: Gary Bloomer, 406-994-7483
This particular isolate, 18ß-Glycyrrhetinic Acid (GRA), accelerates clearance of infection with the enteric rotavirus, a virus that is of significant public health interest.
Double-Mutant Live Attenuated Brucella Vaccines (PDW-2012-LIVE)
Contact: Gary Bloomer, 406-994-7483
A double-mutant brucellosis vaccine for cattle and humans which has two virulence genes attenuated to enable minimal infection and a marker gene to enable identification of the vaccine from wild type pathogen. This vaccine is more effective and more attenuated than current vaccines.
Mechanobiology Instrument for Applying Compression to a Cell Sample Under Microscopy (JRK-2012-HMLA)
Contact: Gary Bloomer, 406-994-7483
An inexpensive, versatile and robust device, mountable on a microscope stage, to apply compressive loads to biological samples.
Thermostable Site-Specific Integrase (LCM-2012-SSV)
Contact: Nick Zelver, 406-994-7706
An archeal tyrosine recombinase that may lead the way to producing superior site-specific recombinases for biotech applications.
Norovirus and Snow Mountain Virus Antibodies Available for Licensing (HME-2004-SNOW, HME-2003-NORW)
Contact: Nick Zelver, 406-994-7706
Novel Agents to Enhance Tolerance to an Immunogen (PDW-2006-TOLE)
Contact: Nick Zelver, 406-994-7706
A new apprach to developing highly potent, antigen-specific agents, called "tolerizing agents", uses a mucosal targeting ligand fused to a specific antigen to induce host unresponsiveness solely to that antigen while avoiding global immune suppression.
Quaternary Ammonium Complex Provides Superior Broad Spectrum Antimicrobial Activity (CMJ-2005-CARB)
Contact: Nick Zelver, 406-994-7706
Binding biocide to soluble dendrimers targets and disrupts the cell wall providing a new approach to controlling household, industrial, and medical microorganisms.
Enhanced Innate Resistance to Infections (JMA-2006-TLRS)
Contact: Nick Zelver, 406-994-7706
Natural, non-toxic compounds trigger innate immunity to bacterial, viral, fungal, or parasitic infection.
Mouse Monoclonal Antibodies
Contact: Nick Zelver, 406-994-7706
Anti-gp91phox, Anti-p22phox and Anti- CAP-18
