Alyssa Carlson PhD Comp Exam Presentation
- Wednesday, October 25, 2017 at 9:00am
- Wilson Hall, Room 1-131 - view map
Characterizing Metabolic Changes in Osteoarthritic Synovial Fluid using Liquid-Chromatography-Mass Spectrometry
Osteoarthritis affects over 250 million individuals worldwide, is the leading cause of workplace disability, and is associated with an enormous economic burden. Currently osteoarthritis is diagnosed by radiography when patients report joint pain and/or loss of function. Diagnosis at this stage of disease is associated with irreversible cartilage degradation, leaving joint replacements as the only treatment option. Thus, we need new methods for diagnosing osteoarthritis earlier in disease progression.
Biomarkers of osteoarthritis would be useful for early diagnosis, tracking disease progression, and determining treatment effectiveness. There are currently no known biomarkers of osteoarthritis used in the clinic. Thus, we are proposing to use global metabolomic profiling for biomarker discovery for osteoarthritis. Global metabolomic profiling of osteoarthritic synovial fluid will give insight into disease pathophysiology and identify many metabolites as candidate biomarkers.
- Department of Mechanical & Industrial Engineering