Safiye Ozcan, MS Thesis Defense, Chemical & Biological Engineering
- Friday, May 4, 2018 from 10:00am to 11:00am
- Barnard Hall, 323 - view map
"Quorum Quenching as a Promising Method to Control Biofilm Growth in Metalworking Fluids"
ABSTRACT: Microbial contamination in metalworking fluid (MWF) circulation systems is a serious problem in the machining industry. In particular, water based MWFs promote microbial colonization despite the use of biocides. Quenching the quorum sensing mechanism (i.e. cell-cell communication) in bacteria is a promising approach to control and prevent biofilm formation. The objective of this study was (i) to determine the microbial community in MWFs from operational machining shops, (ii) to investigate the effect of well-known quorum sensing inhibitors on controlling biofilm formation, and (iii) to implement experimental data from selected enzymes to a computer simulation biofilm accumulation model (BAM). Results from this work highlight the potential effectiveness of quorum quenching as a strategy to reduce biofilms in MWFs.