MBI Fall Seminar Series
- Tuesday, September 18, 2018 from 2:00pm to 3:00pm
- Strand Union Building, Procrastinator Theater - view map
The Department of Microbiology & Immunology presents
Dr. Evgeni Sokurenko, MD, PhD
Department of Microbiology, University of Washington, Seattle, WA
"Clonal Diagnostics of UTI or How to Get Personal with E. coli"
Urinary tract infections (UTIs) – cystitis, pyelonephritis and urosepsis - are caused predominantly by Escherichia coli and account for more than 10 million patient visits per year and 30,000 deaths in USA alone. UTIs afflict most women but cause especially severe infections in young children and the elderly. Due to the rise of multi-drug antibiotic resistance in E. coli, empirical choice of antibiotic treatment becomes less and less accurate, with one in three of UTI treatments resulting in drug-bug mismatch.
E. coli are clonal in nature and circulate as a limited number of separate, closely related families (clonal groups) with a highly similar genomic composition. The antibiotic treatment resistance and also virulence are highly distinctive among these clonal groups. Based on multi-year and multi-site surveillance database compiled by us, we have developed a rapid molecular diagnostics test that identifies presence of E. coli in the patients’ urine and the clonal identity of the infecting bacterial strain. This personalized approach to the pathogen diagnostics reduces drug-bug mismatch rates multi-fold and could prevent severe complications in the patients. It also allows detection in real-time of newly emerging multi-drug resistant strains – pandemic ‘superbugs’
The clonal diagnostics approach represents a paradigm shift in curbing the rise of antibiotic resistance that merges genomics, bioinformatics, surveillance, and diagnostics tools to bring evidence-based medicine directly to the point of care.
- Department of Microbiology & Immunology