CBE Seminar Series: Dr. Ross Carlson
- Thursday, October 11, 2018 from 4:10pm to 5:00pm
- Roberts Hall, 321 - view map
Dr. Ross Carlson is a professor in MSU’s Department of Chemical & Biological Engineering and an affiliated faculty member at the CBE. His research uses a combination of physiological, omics, and stoichiometric network analyses approaches to understand multispecies biofilms. Ross’ talk “Multiscale analysis of resource allocation in chronic wound biofilms,” will focus on his work with chronic wound biofilms.
Abstract: Chronic wounds are host-pathogen environments that fail to heal in a timely manner. These infections are a major health care challenge, costing the US more than $33 billion per year. Chronic wounds are typically colonized by multiple species growing as biofilms. A model consortium comprised of three chronic wound isolates: aerobe Pseudomonas aeruginosa, facultative anaerobe Staphylococcus aureus and obligate anaerobe Clostridium perfringens was studied, and biofilm growth was analyzed using genome-scale, metabolic reconstructions integrated with partial differential equations accounting for metabolite diffusion and consumption. The multiscale, spatiotemporal models quantified the intersection of resource gradients, resource competition and metabolism in multispecies biofilms. The models should enable the predictive testing of emergent properties in biofilms including enhanced nutrient accessibility, nutrient utilization and eventually antibiotic tolerance.
If you would like to meet with Dr. Carlson, please contact him at email@example.com
- Center for Biofilm Engineering