Applied Math Seminar: Analysis of Convective and Diffusive Transport in the Brain Interstitium
- Thursday, October 11, 2018 from 3:10pm to 4:00pm
- Wilson Hall, 1-144 - view map
Applied Math Seminar:
Lori Ray (Chemical and Biological Engineering, MSU)
Title: Analysis of Convective and Diffusive Transport in the Brain Interstitium
Despite advances in in vivo imaging and experimental techniques, physiological transport mechanisms in the smallest regions of the brain remain elusive. In such places, mathematical modelling offers a powerful tool for investigating hypotheses, especially when verified by experimental data. Mechanisms for extracellular transport of molecules in brain tissue is one such place. For decades, the presence of convection, or bulk flow, in the brain interstitium and its role in the transport of solutes has been debated in the literature. Diffusive transport mechanisms are well established and characterized through experimentation. There is support for bulk flow transport in the perivascular spaces surrounding large blood vessels that penetrate brain tissue. However, evidence of bulk flow in the wider brain interstitium is disputed. In this talk we will compare simulations of purely diffusive transport and simulations of combined convective and diffusive transport with the large body of experimental transport data in the literature. The simulations support the possibility of convective, bulk flow in the interstitium that has a similar magnitude as diffusive transport for molecules of interest, and, significantly, simulations provide a likely upper limit for the convective flow magnitude based on currently available experimental measurements.