Department of Chemistry and Biochemistry Seminar
- Friday, February 14, 2020 at 3:10pm
- Chemistry & Biochemistry Building, Byker Auditorium - view map
Dr. Christian Melander, George & Winifred Clark Professor,
Department of Chemistry and Biochemistry, University of Notre Dame will present "Small Molecule Disruption of Bacterial Biofilms and Other Antibiotic Defense Mechanisms."
Abstract: Antibiotic resistance and the rise of antibiotic resistant pathogens are threatening the vast strides we have made over the past century in human medicine. To combat the threatening tide of multi-drug resistant (MDR) bacteria, we have been exploring the use of small molecules based upon naturally occurring nitrogen-dense marine natural products to serve as adjuvants for antibiotic treatment regiments. The talk will detail our efforts to develop small molecule leads that inhibit and disperse bacterial biofilms both in vitro and in vivo, and the application of knowledge gained through mechanistic studies to identify additional small molecules that are able to reverse both acquired and intrinsic resistance in MDR pathogens.
- Department of Chemistry and Biochemistry