Toward Better Genetically Encoded Sensors of Membrane Potential


Douglas Storace, Masoud Sepehri Rad, BokEum Kang, Lawrence B. Cohen, Thom Hughes, Bradley J. Baker


Trends in Neurosciences


Genetically encoded sensors of cell activity are powerful tools that can be targeted to specific cell types. This is especially important in neuroscience because individual brain regions can include a multitude of different cell types. Understanding function will require recording activity from each of the individual cell types in a region. To this end, optical signals of membrane potential are useful because membrane potential changes are a direct sign of both synaptic and action potentials and because optical imaging allows for simultaneous recording from numerous neurons or brain regions. Here we describe recent improvements in the in vitro and in vivo signal size and kinetics of genetically encoded voltage indicators (GEVIs) and discuss their relationship to alternative sensors of neural activity.



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