CAIRHE logo

RFP No.: CAIRHE-05-2018
Issue Date:
 October 9, 2017
Deadline:March 11, 2018

Overview

CAIRHE requests proposals for New Pilot Projects, Continuation Pilot Projects, and 5-year Research Projects that address CAIRHE’s mission of reducing health disparities in tribal and/or nontribal rural communities through community-based participatory research (CBPR) that is considerate of and consistent with their cultural beliefs. Faculty applicants may develop projects within a single discipline (e.g., social sciences), but CAIRHE also encourages collaborative projects between biomedical and social and behavioral health investigators. Projects that involve tribal college students and/or American Indian students at MSU are highly encouraged. As in all CAIRHE-funded research, projects should have a high likelihood of leading to independent funding from external (non-MSU) sponsors, such as the National Institutes of Health, the Patient-Centered OutcomesResearch Institute, or the National Science Foundation.

For pilot projects, CAIRHE will award funding for one grant year (September 1, 2018, through August 31, 2019). First-year pilot projects may have the possibility of competitive renewal for one subsequent year. Pilot projects cannot be funded beyond two years.

Selected 5-year Research Projects will become part of CAIRHE's application to the NIH for a Phase 2 COBRE renewal grant (2019-2024). CAIRHE will submit that application in September 2018, with funding (if awarded) to begin September 1, 2019. Funding of these Research Projects is contingent upon CAIRHE's being awarded a Phase 2 COBRE grant. 

About CAIRHE and Its Faculty

Based at Montana State University, CAIRHE is an official State of Montana research center designated by the Montana University System Board of Regents. CAIRHE is supported by an Institutional Development Award (IDeA)—specifically, a Centers of Biomedical Research Excellence (COBRE) grant—from the National Institute of General Medical Sciences of the National Institutes of Health (grant number 5P20GM104417). For more information, see http://www.montana.edu/cairhe/about/

Funded CAIRHE investigators receive administrative and fiscal support services to assist them with their research, and each junior investigator is paired with a senior faculty mentor with NIH funding experience. The CAIRHE mentoring program requires regular meetings between investigators and mentors, with the ultimate goal being independent funding status through major external grant support. Funded CAIRHE investigators are an integral part of the center and its mission, and participation in center meetings and events is one expectation for our faculty.

Eligibility

Principal investigator applicants must hold a full-time faculty appointment at Montana State University. Individuals holding postdoctoral fellowships or other positions that lack independent faculty status are not eligible to lead COBRE-funded projects.

One of the main objectives of the COBRE grant program is to enhance the ability of junior investigators to compete independently for an NIH individual research grant or other major external peer-reviewed support. For this reason, projects funded by CAIRHE’s NIH grant must involve junior investigators, defined as either (1) an individual who does not have and has not previously had an external, peer-reviewed research project grant or program project grant (R01-level) from either a federal or non-federal source that names that investigator as the PI; or (2) an established investigator who is making a significant change to her/his research career. Most faculty in category 1 are new and early stage investigators. For NIH definitions, see http://grants.nih.gov/policy/new_investigators/index.htm#definition. Please contact CAIRHE if you have any eligibility questions.

All applications should have a strong potential to lead to external (non-MSU) funding.

Faculty in the biomedical and social/behavioral sciences are encouraged to apply. (Please note that salary support for collaborative projects may be limited by overall budget limits.) Due to restrictions imposed by the NIH, faculty who are funded as an investigator by another IDeA program are not eligible for simultaneous CAIRHE funding. This includes project leaders for Montana INBRE and the American Indian–Alaska Native Clinical and Translational Research Program. Please contact CAIRHE if you have questions about this rule.

Application Types

CAIRHE will accept applications in three categories: New Pilot Projects, Continuation Pilot Projects, and 5-Year Research Projects.

New Pilot Projects

Typically funded at approximately $20,000 to $50,000 in direct costs per year, though not more than $99,999, pilot projects are designed for project leaders who do not currently have a CAIRHE grant and do not currently have significant preliminary data or fully established community partnerships. (However, having preliminary data and/or community partnerships in place at the time of the application would be considered an advantage.) Applicants may wish to consult this list of resources about conducting CBPR with tribal communities. We also strongly encourage applicants to consult with CAIRHE Director Alex Adams or Program Coordinator James Burroughs about community engagement plans before making contacts.

New pilot projects may have the possibility of competitive renewal for a second and final year. In most cases, CAIRHE will require that the project leader submit an extramural research project grant proposal after the second pilot project grant period (i.e., after 2 years).

Continuation Pilot Projects

Funded at a variable total for direct costs, though not more than $99,999, continuation pilot projects involve those investigators who have received an initial year of CAIRHE pilot project funding. Researchers who have accumulated substantial preliminary data sufficient for an extramural grant proposal may apply for this mechanism, which is designed primarily to facilitate research publications and extramural grant proposals with less of an emphasis on accumulation of new data. The total direct costs may be lower than those for new pilot projects. According to NIH regulations, pilot project funding cannot extend beyond two years.

All previously funded CAIRHE pilot project investigators must submit, in addition to the proposal requirements listed below, a draft Specific Aims page for a new extramural grant proposal or a recently submitted or revised grant proposal. In cases where there is significant overlap between the extramural grant proposal and the CAIRHE proposal (for example, where the CAIRHE proposal represents one aim of the larger proposed project), then a single Specific Aims page will suffice with an explanation of how the projects relate. Contact CAIRHE if you have questions about this requirement.

Research Projects

These major research projects make up the core of CAIRHE's research mission. Funded at direct costs greater than $100,000 per year for 5 years, these projects are intended to provide junior-faculty project leaders with a solid foundation for a major research project proposal to an external funding agency. According to NIH COBRE guidelines, all research project leaders must submit an investigator-initiated research project grant application (R01-level) to a major external funding agency by the end of two years of COBRE support.

Also according to NIH guidelines, "COBRE research project investigators must make an initial minimum commitment of 6 person months annually. Established investigators must make an initial commitment of at least 3 person months annually. It is recognized that during the development of an investigator's career (for example, the acquisition of other research support) it may be necessary to reduce these levels of commitment, with NIH prior approval." 

IMPORTANT: Before beginning a 5-year Research Project application, you must contact Program Coordinator James Burroughs (jburroughs@montana.edu) to set up an appointment with center leadership to discuss Research Project funding and expectations in more detail.

Proposal Requirements: New and Continuation Pilot Projects

Forms and complete instructions for proposal applications can be found on the CAIRHE website at  http://www.montana.edu/cairhe/rfp/instructions.html. Please adhere to page limits and other guidelines given in the instructions.

Applications for New and Continuation Pilot Project proposals should include the following using PHS 398 forms (a federal forms package) and instructions:

  • Face Page.
  • Project Summary.
  • Specific Aims.
  • Research Strategy (Significance, Innovation, Approach), with Bibliography (if applicable).
  • Protocol Addressing Protection of Human Subjects.
  • IRB approval, human subjects education certification for PIs and key personnel, and Inclusion Enrollment Report (if applicable).
  • One-year budget and justification.
  • Other Support.

In addition, the application may need to include:

  • IACUC approval and Vertebrate Animal Section (if applicable).

Proposal Requirements: 5-Year Research Projects

Forms and complete instructions for proposal applications can be found on the CAIRHE website at  http://www.montana.edu/cairhe/rfp/instructions-5-year.html. Please adhere to page limits and other guidelines given in the instructions.

Applications for Research Project proposals should include the following using PHS 398 forms (a federal forms package) and instructions:

  • Face Page.
  • Project Summary.
  • Specific Aims.
  • Research Strategy (Significance, Innovation, Approach), with Bibliography (if applicable).
  • Protocol Addressing Protection of Human Subjects.
  • IRB approval, human subjects education certification for PIs and key personnel, and Inclusion Enrollment Report (if applicable).
  • Biographical Sketch for PIs and key personnel.
  • Five-year detailed budget and justification.
  • Other Support.

In addition, the application may need to include:

  • Specific plans for data and safety monitoring, if the proposed project involves clinical trials.
  • IACUC approval and Vertebrate Animal Section (if applicable).

Deadline and Submission Requirements

An electronic version of the complete proposal in Microsoft Word format (not PDF, with the exception of one form), with each section as a separate file, should be submitted no later than midnight on March 11, 2018, to James Burroughs (994-4407, jburroughs@montana.edu). Please contact him or Dr. Alex Adams, CAIRHE director (994-6077, alexandra.adams2@montana.edu), if you have questions about the proposal format or instructions, or if you would like to discuss potential project ideas.

Proposal Review

Proposals will be reviewed by CAIRHE’s director and principal investigator, as well as other members of the Administrative and Community Engagement Cores. Proposals will be evaluated based on scientific merit, relevance to CAIRHE's mission, and the impact of the proposed project on the potential for future independent funding. Final review will be conducted by CAIRHE’s External Advisory Committee, who will prioritize proposals for NIH review and funding.

CAIRHE will send the full application for each new or continuation pilot project finalist to the National Institutes of Health, National Institute of General Medical Sciences, for ultimate approval in the Spring/Summer of 2018. CAIRHE will then inform applicants of the funding decision, with funding to begin September 1, 2018, for those projects selected.

CAIRHE will include chosen research projects in its application for a COBRE renewal grant, to be submitted in September 2018. CAIRHE should receive the NIH's funding decision by June 2019, with project funding to begin no sooner than September 1, 2019.

All CAIRHE awards are contingent upon the availability of NIH funding. For all project types, research funding must be expended by the end of each budget year (September 1 through August 31). No carryover is allowed from one budget year to the next due to NIH regulations. Successful first-year pilot project leaders will need to apply for second-year funding to continue their projects. CAIRHE will solicit continuation pilot project proposals from project leaders during the first grant year using an RFP similar to this one. These continuation project grants will be awarded through the competitive process described above.