Chang Soft Matter and Microfluidics Lab

Welcome to the Chang Lab @ Montana State University!

January 2017: The Chang Lab has openings for 2 postdoctoral research associate in a DARPA funded project studying the population dynamics of influenza in order to engineer viruses for use as therapeutic particles. Candidates will be part of a multidisciplinary team and will have the opportunity to collaborate with virologists, mathematicians, evolutionary biologists, and materials scientists. Highly motivated, creative individuals are encouraged to apply. One position will start in March/April of 2017 and a second in early 2018. Please email Dr. Chang and apply online here.

Our lab is multidisciplinary, highly collaborative, and encompasses engineering, materials, physics, chemistry, and biology. Some of our projects include single cell sorting. This includes algal cells as a promising alternative to current biofuels, hibernating bacterial cells in a population of cells within a biofilm, and host cells containing undiscovered viruses from Yellowstone. All of these topics fall within the realm of high-throughput discovery and evolution of new biological species with exceptional properties. We are also interested in single cell genomics, which encompasses "omics" or next-generation sequencing of genomes, metabolites, and proteins in biology.

We work on biomaterials. One topic is understanding the growth and mechanics of "organoids", three-dimensional mini-organs that are derived from stem cells. We are using microfluidic techniques to culture and screen these organoids. 

Much of our work involves drop-based microfluidics, a unique method that creates picoliter-sized, monodisperse emulsions in which we can encapsulate and assay single cells. We need a high-speed camera to view the drops being formed. Here are videos of some ways in which we can manipulate drops (these videos are slowed down by 1000):