Chang Soft Matter and Microfluidics Lab
Welcome to the Chang Lab @ Montana State University!
Our lab is multidisciplinary, highly collaborative, and encompasses engineering, materials, physics, chemistry, and biology. Our projects include single cell sorting of algal cells as a promising alternative to current biofuels, hibernating bacterial cells in a population of cells within a biofilm, and host cells containing undiscovered viruses from Yellowstone. All of these topics fall within the realm of high-throughput discovery and evolution of new biological species with exceptional properties. We are also interested in single cell genomics, which encompasses "omics" or next-generation sequencing of genomes, metabolites, and proteins in biology.
We work on biomaterials. One topic is understanding the growth and mechanics of "organoids", three-dimensional mini-organs that are derived from stem cells. We are using microfluidic techniques to culture and screen these organoids.
Much of our work involves drop-based microfluidics, a unique method that creates picoliter-sized, monodisperse emulsions in which we can encapsulate and assay single cells. We need a high-speed camera to view the drops being formed. Here are videos of some ways in which we can manipulate drops (these videos are slowed down by 1000):