Chang Soft Matter and Microfluidics Lab

Welcome to the Chang Lab @ Montana State University!

Our lab is multidisciplinary, highly collaborative, and encompasses engineering, materials, physics, chemistry, and biology. We are currently looking for talented graduate students. Interested students should email Dr. Chang.

Our lab works on single cell sorting. This includes algal cells as a promising alternative to current biofuels, hibernating bacterial cells in a population of cells within a biofilm, and host cells containing undiscovered viruses from Yellowstone. All of these topics fall within the realm of high-throughput discovery and evolution of new biological species with exceptional properties. We are also interested in single cell genomics, which encompasses "omics" or next-generation sequencing of genomes, metabolites, and proteins in biology.

We work on biomaterials. One topic is understanding the growth and mechanics of "organoids", three-dimensional mini-organs that are derived from stem cells. We are using microfluidic techniques to culture and screen these organoids. 

Much of our work involves drop-based microfluidics, a unique method that creates picoliter-sized, monodisperse emulsions in which we can encapsulate and assay single cells. We need a high-speed camera to view the drops being formed. Here are videos of some ways in which we can manipulate drops (these videos are slowed down by 1000):