Mark Quinn


Office: 125 Molecular Bioscience Building
Phone: (406) 994-4707


Research Interests

Our research is focused on understanding microbicidal mechanisms utilized by innate immune cells in defense of the host against pathogens.  Specific projects are in progress to investigate the molecular and biochemical basis of phagocyte oxygen radical production, as well as the role of phagocyte-generated oxidants in the tissue damage associated with inflammatory diseases in humans and livestock.  Additional work focuses on identifying and characterizing novel immunomodulatory agents for enhancing innate immune responses and treating diseases.


  • B.A. Point Loma College, San Diego, CA; 1982; Biology and Chemistry
  • Ph.D. University of California, San Diego, CA; 1987; Physiology and Pharmacology
  • Postdoctoral Fellow. Research Institute of Scripps Clinic, La Jolla, CA; 1987-1989; Biochemistry

Professional Experience

  • Research Institute of Scripps Clinic, La Jolla, CA; 2/88-6/89; Postdoctoral Research Associate
  • Montana State University, Bozeman; 7/89-12/90; Senior Research Associate
  • Montana State University, Bozeman; 1/91-3/31/95; Assistant & Associate Research Professor
  • Montana State University, Bozeman; 4/1/95-6/30/98; Assistant Professor
  • Montana State University, Bozeman; 7/1/98-present; Associate Professor
  • Montana State University, Bozeman; 7/1/00-7/31/01; Interim Department Head
  • Montana State University, Bozeman; 7/05-Present; Professor
  • Montana State University, Bozeman; 10/05-10/06; Interim Department Head
  • Montana State University, Bozeman; 11/06-06/14; Department Head
  • Montana State University, Bozeman; 11/13-Present; WIMU Veterinary Program Director

Honors and Awards

  • 1980 Point Loma College President's Scholarship
  • 1981 Point Loma College Research Associates Summer Research Fellowship
  • 1982-1983 University of California Regents Fellowship
  • 1983-1986 National Science Foundation Graduate Fellowship
  • 1986-1987 San Diego and Graduate Opportunity Research Fellowship
  • 1987-1988 U.S. Public Health Service Predoctoral Traineeship
  • 1988-1989 U.S. Public Health Service Postdoctoral Traineeship
  • 1993 Charles and Nora Wiley Award for Meritorious Research
  • 1997-2000 Member National Arthritis Foundation Biochemistry Grant Study Section
  • 2000 Member MONTS Grant Review Panel
  • 2000 Invited International Bioethics Institute, Lisbon, Portugal
  • 2001-2003 Member National Arthritis Foundation Inflammation Grant Study Section
  • 2001 Invited Speaker, ASN/ISN World Congress of Nephrology, San Francisco, CA
  • 2002-2007 The Journal of Biological Chemistry Editorial Board
  • 2002 Invited Speaker, Oxidases in Inflammation & Cellular Signaling, Cold Spring Harbor
  • 2003-2005 Panelist USDA Competitive Grant Program Animal Health Study Section
  • 2003-2006 VA Merit Review Subcommittee for General Medical Sciences
  • 2004 NIH Special RFA Study Section Member
  • 2006 NIH ELB Study Section Ad Hoc Member
  • 2007 USDA Animal Biosecurity Coordinated Agricultural Project Study Section
  • 2008 Invited Speaker, Nox Family NADPH Oxidases Gordon Conference, New London, NH
  • 2009-2014 The Journal of Biological Chemistry Editorial Board
  • 2009-present The Journal of Leukocyte Biology Editorial Board

Extramural Grant Activity

  • 1989-1991 Arthritis Foundation Postdoctoral Fellowship
  • 1989 American Cancer Society Research Grant
  • 1991-1993 Arthritis Foundation Investigator Award
  • 1991-1993 American Lung Association Research Grant
  • 1992-1997 National Institutes of Health FIRST Award
  • 1994-1997 Arthritis Foundation Biomedical Science Grant
  • 1995-1998 USDA Competitive Research Grant
  • 1996-2001 American Heart Association Established Investigator Award
  • 1996-2001 National Institutes of Health R01
  • 1997-2000 Arthritis Foundation Biomedical Science Grant
  • 1997-1998 National Science Foundation Biological Instrumentation Grant
  • 1997-1998 USDA Shared Instrumentation Grant
  • 1998-1999 Baxter Healthcare Corporation Research Grant
  • 1999-2001 USDA Competitive Research Grant
  • 2000-2001 USDA Shared Instrumentation Grant
  • 2000-2002 USDA Competitive Research Grant
  • 2000-2004 National Institutes of Health R01
  • 2003-2009 National Institutes of Health R01
  • 2006-2007 USDA Shared Instrumentation Grant
  • 2007-2008 M.J. Murdock Charitable Trust
  • 2009-2014 NIH COBRE Program
  • 2014-2015 M.J. Murdock Charitable Trust Instrumentation Grant
  • 2014-2019 National Institutes of Health COBRE P30

Selected Publications

  1. Maeda, D.Y., Quinn, M.T., Scheptekin, I.A., Kirpotina, L.N., and Zebala, J.A. (2010) Nicotinamide Glycolates Antagonize CXCR2 Activity Through an Intracellular Mechanism. J. Pharmacol. Exp. Therapeut.332: 145-152.
  2. Kirpotina, L.N., Khlebnikov, A.I., Schepetkin, I.A., Ye, R.D., Rabiet, M.J., Jutila, M.A., and Quinn, M.T. (2010) Identification of Novel Small-Molecule Agonists for Human Formyl Peptide Receptors and Pharmacophore Models of their Recognition. Mol. Pharmacol.77: 159-170.
  3. Montezano, A.C., Burger, D., Paravicini, T.M., Chignalia, A.Z., Yusuf, H., Almasri, M., He, Y., Callera, G.E., He, G., Krause, K.-H., Lambeth, D., Quinn, M.T., Touyz. R.M. (2010) Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 5 (Nox5) Regulation by Angiotensin II and Endothelin-1 is Mediated via Calcium/Calmodulin-dependent, Rac1-independent Pathways in Human Endothelial Cells. Circ. Res.106: 1363-1373.
  4. Khlebnikov, A.I., Schepetkin, I.A., and Quinn, M.T. (2010) Computational Structure-activity Relationship Analysis of Small-Molecule Agonists for Human Formyl Peptide Receptors. Eur. J. Med. Chem.45: 5406-5419.
  5. Schepetkin, I.A., Kirpotina, L.N., Khlebnikov, A.I., Jutila, M.A., and Quinn, M.T. (2011) Gastrin-Releasing Peptide/Neuromedin B Receptor Antagonists, PD176252 and PD168368, and Related Analogs are Potent Agonists of Human Formyl-Peptide Receptors.  Mol. Pharmacol.79: 77-90.
  6. Yu, P., Han, W., Villar, V.A.M., Li, H., Arnaldo, F.B., Concepcion, G.P., Felder, R.A., Quinn, M.T., and Jose, P.A. (2011) Dopamine D1 receptor-mediated inhibition of NADPH oxidase activity in human kidney cells occurs via protein kinase A-protein kinase C cross-talk. Free Radic. Biol. Med.50: 832-840.
  7. Holderness, J., Schepetkin, I.A., Freedman, B., Kirpotina L.N., Quinn, M.T., Hedges, J.F., and Jutila, M.A. (2011) Polysaccharides Isolated From Acai Fruit Induce Innate Immune Responses. PLoS ONE6: e17301.
  8.  Briones, A.M., Tabet, F., Callera, G.E., Montezano, A.C., Yogi, A., He, Y., Quinn, M.T., Salaices, M., and Touyz, R.M. (2011) Differential regulation of Nox1, Nox2 and Nox4 in vascular smooth muscle cells from WKY and SHR. J. Am. Soc. Hypertens. 5: 137-153.
  9.  Crocetti, L., Giovannoni, M.P., Schepetkin, I.A., Quinn, M.T., Khlebnikov, A.I., Cilibrizzi, A., Dal Piaz, V., Graziano, A., and Vergelli, C. (2011) Design, Synthesis and Evaluation of N-Benzoylindazole Derivatives and Analogues as Inhibitors of Human Neutrophil Elastase. Bioorg. Med. Chem.19: 4460-4472.
  10. Liu, M., Zhu, H., Garcia, C.C., Kirpotina, L.N., Hilmer, J., Tavares, L.P., Layton, A.W., Quinn, M.T., Bothner, B., Teixeira, M.M., and Lei, B. (2012) Group A Streptococcus Secreted Esterase Hydrolyzes Platelet-Activating Factor to Impede Neutrophil Recruitment and Facilitate Innate Immune Evasion.  PLoS Pathogens 8: e1002624.
  11. Khlebnikov, A.I., Schepetkin, I.A., Kirpotina, L.N., Brive, L., Dahlgren, C., Jutila, M.A., and Quinn, M.T. (2012) Molecular Docking of 2-(Benzimidazol-2-ylthio)-N-phenyl-acetamide-Derived Small-Molecule Agonists of Human Formyl Peptide Receptor 1. J. Mol. Modeling18: 2831-2843.
  12. Schepetkin, I.A., Kirpotina, L.N., Khlebnikov, A.I., Hanks, T., Kochetkova, I., Pascual, D.W., Jutila, M.A., and Quinn, M.T. (2012) Identification and Characterization of a Novel Class of c-Jun N-terminal Kinase Inhibitors. Mol. Pharmacol.81: 832-845.
  13. Lai, E.Y., Luo, Z., Onozato, M., Rudolph, E., Solis, G., Jose, P., Wellstein, A., Aslam, S., Quinn, M.T., Griendling, K., Le, T., Li, P., Palm, F., Welch, W., and Wilcox, C. (2012) Effects of the Antioxidant Drug Tempol on Renal Oxygenation in Mice with Reduced Renal Mass.  Am. J. Physiol.-Renal Physiol.303: F64-F74.
  14. Cilibrizzi, A., Schepetkin, I.A., Bartolucci, G., Crocetti, L., Dal Piaz, V., Giovannoni, M.P., Graziano, A., Kirpotina, L.N., Quinn, M.T., and Vergelli, C. (2012) Synthesis, Enantioresolution, and Activity Profile of Chiral 6-Methyl-2,4-Disubstituted Pyridazin-3(2H)-ones as Potent N-Formyl Peptide Receptor Agonists. Bioorg. Med. Chem.20: 3781-3792.
  15. Graves, S.F., Kobayashi, S.D., Braughton, K.R., Whitney, A.R., Sturdevant, D.E.,  Rasmussen, D.L., Kirpotina, L.N., Quinn, M.T., and DeLeo, F.R. (2012) Sublytic concentrations of Staphylococcus aureus Panton-Valentine Leukocidin Alter Human PMN Gene Expression and Enhance Bactericidal Capacity. J. Leukoc. Biol.92: 361-374.
  16. Ramstead, A.G., Schepetkin, I.A., Quinn, M.T., and Jutila, M.A. (2012) Oenothein B, a Cyclic Dimeric Ellagitannin Isolated from Epilobium angustifolium, Enhances IFNγ Production by Lymphocytes.  PLoS One 7: e50546.
  17. Schepetkin, I.A., Kirpotina, L.N., Khlebnikov, A.I., Leopoldo, M., Lucente, E., Lacivita, E., De Giorgio, P., and Quinn, M.T. (2013) 3-(1H-Indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide Enantiomers With Human Formyl-Peptide Receptor Agonist Activity: Molecular Modeling of Chiral Recognition by FPR2. Biochem. Pharmacol.85: 404-416.
  18. Kouakou, K., Schepetkin, I.A., Yapi, A., Kirpotina, L.N., Jutila, M.A., and Quinn, M.T. (2013) Immunomodulatory Activity of Polysaccharides Isolated from Alchorneacordifolia. J. Ethnopharmacol.146: 232-242.
  19. Cilibrizzi, A., Crocetti, L., Giovannoni, M.P., Graziano, A.,Vergelli, C.,Bartolucci, G., Soldani, G., Quinn, M.T., Schepetkin, I.A., and Faggi, C. (2013) Synthesis, HPLC Enantioresolution, and X-ray Analysis of a New Series of C5-methyl Pyridazines as N-Formyl Peptide Receptor (FPR) Agonists. Chirality25: 400-408.
  20. Schepetkin, I.A., Kouakou, K., Yapi, A., Kirpotina, L.N., Jutila, M.A., and Quinn, M.T. (2013) Immunomodulatory and Hemagglutinating Activities of Acidic Polysaccharides Isolated from Combretum racemosum. Int. Immunopharmacol.15: 628-637.
  21. Crocetti, L., Vergelli, C., Cilibrizzi, A., Graziano, A., Khlebnikov, A., Kirpotina, L., Schepetkin, I., Quinn, M., and Giovannoni, M.P. (2013) Synthesis and Pharmacological Evaluation of New Pyridazin-based Thioderivatives as FPR Agonists. Drug Dev. Res., 74: 259-271.
  22. Giovannoni, M.P., Schepetkin, I.A., Cilibrizzi, A., Crocetti, L., Khlebnikov, A.I., Dahlgren, C., Graziano, A., Dal Piaz, V., Kirpotina, L.N., Zerbinati, S., Vergelli, C., and Quinn, M.T. (2013) Further Studies on 2-Arylacetamide Pyridazin-3(2H)-ones: Design, Synthesis and Evaluation of 4,6-Disubstituted Analogues as Formyl Peptide Receptors (FPRs) Agonists. Eur. J. Med. Chem.64: 512-528.
  23. Kouakou, K., Schepetkin, I.A., Jun, S., Kirpotina, L.N., Yapi, A., Khramova, D.S., Pascual, D.W., Ovodov, Y.S., Jutila, M.A., and Quinn, M.T. (2013) Immunomodulatory activity of polysaccharides isolated from Clerodendrum splendens: Beneficial effects in experimental autoimmune encephalomyelitis. BMC Complement. Altern. Med.13: 149.
  24. Crocetti, L., Schepetkin, I.A., Cilibrizzi, A., Graziano, A., Vergelli, C., Giomi, D., Khlebnikov, A.I., Quinn, M.T., and Giovannoni, M.P. (2013) Optimization of N-Benzoylindazole Derivatives as Inhibitors of Human Neutrophil Elastase. J. Med. Chem., 56: 6259-6272.
  25. Munnamalai, V., Weaver, C.J., Weisheit, C.E., Venkatraman, P., Agim, Z.S., Quinn, M.T. and Suter, D.M. (2014) Bidirectional interactions between NOX2-type NADPH oxidase and the F-actin cytoskeleton in neuronal growth cones. J. Neurochem. 130: 526-540.
  26. Yu, P., Han, W., Villar, V.A.M., Yu, Y., Lu, Q., Lee, H., Li, F., Quinn, M.T., Gildea, J.J., Felder, R.A., and Jose, P.A. (2014) Unique role of NADPH oxidase 5 in oxidative stress in human renal proximal tubule cells. Redox Biol.2: 570-579.
  27. Maeda, D.Y., Peck, A.M., Schuler, A.D., Quinn, M.T., Kirpotina, L.N., Wicomb, W.N., Fan, G.H., and Zebala, J.A. (2014) Discovery of 2-[5-(4-Fluoro-phenylcarbamoyl)-pyridin-2-ylsulfanylmethyl]-phenylboronic acid (SX-517): A Non-Competitive Boronic Acid Antagonist of CXCR1 and CXCR2. J. Med. Chem. 57: 8378-8397.
  28. Schepetkin, I.A., Kirpotina, L.N., Khlebnikov, A.I., Cheng, N., Ye, R.D., and Quinn, M.T. (2014) Antagonism of Human Formyl Peptide Receptor 1 (FPR1) by Chromones and Related Isoflavones. Biochem. Pharmacol.92: 627-641.
  29. Lacivita, E., Schepetkin, I.A., Stama, M., Kirpotina, L.N., Colabufo, N.A., Quinn, M.T., and Leopoldo, M. (2015) Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido] propanamides as Selective Agonists of Human Formyl-Peptide Receptor 2. Bioorg. Med. Chem., In press.
  30. Schepetkin, I.A., Kirpotina, L.N., Hammaker, D., Kochetkova, I., Khlebnikov, A.I., Lyakhov, S.A., Firestein, G.S., and Quinn, M.T. (2015)  Anti-Inflammatory Effects and Joint Protection in Collagen-induced Arthritis Following Treatment with IQ-1S, a Selective c-Jun N-terminal Kinase Inhibitor. J. Pharmacol. Exp. Ther., In press.

Recent Reviews

  • Quinn, M.T. and Schepetkin, I.A. (2009) Role of NADPH Oxidase in Formation and Function of Multinucleated Giant Cells. J. Innate Immun.1: 509-526.
  • Lu, T., Kobayashi, S.D., Quinn, M.T., and DeLeo, F.R. (2012) A NET Outcome. Front. Immunol. 3: 365.
  • Schepetkin, I.A., Khlebnikov, A.I., Giovannoni, M.P., Kirpotina, L.N., Cilibrizzi, A., and Quinn, M.T. (2014) Development of Small Molecule Non-peptide Formyl Peptide Receptor (FPR) Ligands and Molecular Modeling of Their Recognition. Curr. Med. Chem., 21: 1478-504.

Recent Book Edits

  • Quinn, M.T. and DeLeo, F.R., Eds. (2014) Neutrophil Methods and Protocols, 2nd Edition. Humana Press, New York.