Recent Publications SREBP Coordinates Iron and Ergosterol Homeostasis to Mediate Triazole Drug and Hypoxia Responses in the Human Fungal Pathogen Aspergillus fumigatus. Blatzer M., Barker B.M., Willger S.D., Beckmann N., Blosser S.J., Cornish E.J., Mazurie A., Grahl N., Haas H., Cramer R.A. PLoS Genetics. 2011 Dec 1;7:12 e1002374 In vivo Hypoxia and a fungal Alcohol Dehydrogenase Influence the Pathogenesis of Invasive Pulmonary Aspergillosis. Grahl N., Puttikamonkul S., Macdonald J.M., Gamcsik M.P., Ngo L.Y., Hohl T.M., Cramer R.A. PLoS Pathogens. 2011 Jul 21;7:7 e1002145 Trehalose 6-phosphate phosphatase is required for cell wall integrity and fungal virulence but not trehalose biosynthesis in the human fungal pathogen Aspergillus fumigatus. Puttikamonkul S., Willger S.D., Grahl N., Perfect J.R., Movahed, N., Bothner, B., Park, S., Paderu, P., Perlin, D.S., and Cramer, R.A. Molecular Microbiology. 2010 Jun 9;77:891-911. Computational structure-activity relationship analysis of small-molecule agonists for human formyl peptide receptors. Khlebnikov A.I., Schepetkin I.A., Quinn M.T. Eur J Med Chem. 2010 Nov;45(11):5406-19. A stereocontrolled synthesis of (±)-xenovenine via a scandium(III)-catalyzed internal aminodiene bicyclization terminated by a 2-(5-ethyl-2-thienyl)ethenyl group. Jiang T., Livinghouse T. Org Lett. 2010 Oct 1;12(19):4271-3. Hepatocytes lacking thioredoxin reductase 1 have normal replicative potential during development and regeneration. Rollins M.F., van der Heide D.M., Weisend C.M., Kundert J.A., Comstock K.M., Suvorova E.S., Capecchi M.R., Merrill G.F., Schmidt E.E.. J Cell Sci. 2010 Jul 15;123(Pt 14):2402-12. Adenovirus F protein as a delivery vehicle for botulinum B. Clapp B., Golden S., Maddaloni M., Staats H.F., Pascual D.W. BMC Immunol. 2010 Jul 7;11:36. Role of CD4+ and CD8+ T cells in clearance of primary pulmonary infection with Coxiella burnetii. Read A.J., Erickson S., Harmsen A.G.. Infect Immun. 2010 Jul;78(7):3019-26. IL-35 stimulation of CD39+ regulatory T cells confers protection against collagen II-induced arthritis via the production of IL-10. Kochetkova I., Golden S., Holderness K., Callis G., Pascual D.W. J Immunol. 2010 Jun 15;184(12):7144-53. Type-I IFN signaling suppresses an excessive IFN-gamma response and thus prevents lung damage and chronic inflammation during Pneumocystis (PC) clearance in CD4 T cell-competent mice. Meissner N., Swain S., McInnerney K., Han S., Harmsen A.G. Am J Pathol. 2010 Jun;176(6):2806-18. A parenteral DNA vaccine protects against pneumonic plague. Yamanaka H., Hoyt T., Yang X., Bowen R., Golden S., Crist K., Becker T., Maddaloni M., Pascual D.W. Vaccine. 2010 Apr 19;28(18):3219-30. Prion shedding from olfactory neurons into nasal secretions. Bessen R.A., Shearin H., Martinka S., Boharski R., Lowe D., Wilham J.M., Caughey B., Wiley J.A. PLoS Pathog. 2010 Apr 15;6(4):e1000837. Spectroscopic identification of heme axial ligands in HtsA that are involved in heme acquisition by Streptococcus pyogenes. Ran Y., Liu M., Zhu H., Nygaard T.K., Brown D.E., Fabian M., Dooley D.M., Lei B. Biochemistry. 2010 Apr 6;49(13):2834-42. Modulation of PLAGL2 transactivation by positive cofactor 2 (PC2), a component of the ARC/Mediator complex. Wezensky S.J., Hanks T.S., Wilkison M.J., Ammons M.C., Siemsen D.W., Gauss K.A. Gene. 2010 Feb 15;452(1):22-34. Regulation of hypoxia adaptation: an overlooked virulence attribute of pathogenic fungi? Grahl N., Cramer R.A. Jr. Med Mycol. 2010 Feb;48(1):1-15. Review. Identification of novel small-molecule agonists for human formyl peptide receptors and pharmacophore models of their recognition. Kirpotina L.N., Khlebnikov A.I., Schepetkin I.A., Ye R.D., Rabiet M.J., Jutila M.A., Quinn M.T. Mol Pharmacol. 2010 Feb;77(2):159-70. DeltaznuADeltapurE Brucella abortus 2308 mutant as a live vaccine candidate. Yang X., Thornburg T., Walters N., Pascual D.W. Vaccine. 2010 Jan 22;28(4):1069-74. SaeR binds a consensus sequence within virulence gene promoters to advance USA300 pathogenesis. Nygaard T.K., Pallister K.B., Ruzevich P., Griffith S., Vuong C., Voyich J.M.. J Infect Dis. 2010 Jan 15;201(2):241-54. IL-28 supplants requirement for T(reg) cells in protein sigma1-mediated protection against murine experimental autoimmune encephalomyelitis (EAE). Rynda A., Maddaloni M., Ochoa-Repáraz J., Callis G., Pascual D.W. PLoS One. 2010 Jan 14;5(1):e8720. Decreased necrotizing fasciitis capacity caused by a single nucleotide mutation that alters a multiple gene virulence axis. Olsen R.J., Sitkiewicz I., Ayeras A.A., Gonulal V.E., Cantu C., Beres S.B., Green N.M., Lei B., Humbird T., Greaver J., Chang E., Ragasa W.P., Montgomery C.A., Cartwright J. Jr, McGeer A., Low D.E., Whitney A.R., Cagle P.T., Blasdel T.L., DeLeo F.R., Musser J.M.. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):888-93. Nicotinamide glycolates antagonize CXCR2 activity through an intracellular mechanism. Maeda D.Y., Quinn M.T., Schepetkin I.A., Kirpotina L.N., Zebala J.A. J Pharmacol Exp Ther. 2010 Jan;332(1):145-52.