Kopriva Science Seminar Series, Rachel Rawle
- Monday, January 14, 2019 at 4:10pm
- Chemistry & Biochemistry Building, Byker Auditorium - view map
Rachel Rawle, a doctoral student in the Department of Microbiology and Immunology and recipient of a 2017 Kopriva Graduate Student Fellowship, will present "Microbial Interactions With Arsenic in the Environment and Inside Your Body" as part of the College of Letters and Sciences's Kopriva Science Seminar Series.
The toxicity, bioavailability and mobility of arsenic are directly dependent on its chemical speciation. Long-standing research has determined microbes as the principal drivers of arsenic speciation in virtually all environments studied, with important speciation events occurring in soil and water systems that directly affect agricultural and human exposures. Recent studies show human-associated microbiomes likely play a similar role in arsenic redox chemistry, particularly within the gastrointestinal tract (gut). While these studies show that gut microbiota impact the toxicity and uptake of arsenic into the host, the underlying mechanisms are only theoretical at this juncture. Rawle's research is focused on two important aspects of arsenic-microbial interactions: 1) characterizing the metabolic response of soil bacteria to arsenic exposure using model organism Agrobacterium tumefaciens 5A, and 2) assessing the role of gut bacteria in arsenic-exposed mouse models to determine microbial and host contributions to arsenic metabolism.
A reception will follow the lecture.
Rawle’s lecture is presented by the Kopriva Science Seminar Series, which is funded through an endowment created by Phil Kopriva, a 1957 microbiology graduate from MSU. Kopriva, who died in 2002, also created an endowment to fund the Kopriva Graduate Fellowship Program, which provides support and opportunities for graduate students in the College of Letters and Science, particularly in the biomedical sciences. The series features seminars by MSU graduate students, faculty members and guest speakers.