Department of Chemistry and Biochemistry Seminar
- Friday, March 29, 2019 at 3:10pm
- Chemistry & Biochemistry Bldg, Byker - view map
Dr. Elliott Hulley (University of Wyoming) will present "Application of FLP Design Strategies to Organometallic Transformations."
Abstract: Metal-carbon bond formation is one of the most important steps in organometallic catalysis, particularly when formed by C-H activation. Understanding the free-energy landscapes of chemical transformations is critical for catalyst design and improvement. Our laboratory has been investigating the thermodynamics of C-H heterolysis, operative in many catalytic C-H functionalizations, using tunable pairs of electrophilic metal complexes and basic proton acceptors (analogous to main group Frustrated Lewis Pairs, FLPs). Advantageous use of FLP-inspired transition metal frameworks requires balancing nucleophile/substrate interactions against the nucleophile/metal interactions that quench metal reactivity and block binding sites. In this talk, recent developments in understanding how C-H bond acidities change upon metal coordination will be discussed, particularly within the context of catalytic organic transformations.
- Department of Chemistry and Biochemistry