CBE Seminar: Geometry dependent instabilities of waves in excitable media
- Thursday, March 28, 2019 from 4:10pm to 5:00pm
- Roberts Hall, 301 - view map
Stephanie Dodson is a PhD candidate in the Division of Applied Mathematics at Brown University, where she works with Professor Björn Sandstede.
Traveling waves in excitable media have important applications in cardiac and neurodynamics, but the impact of domain geometry on the observed types of firing patterns is rarely studied. This talk will present results from experiments and simulations of an engineered eclectically excitable cell line, which grown in patterned islands of different shapes shows remarkably diverse firing patterns under otherwise identical conditions, including regular spiking, period-doubling alternans, and arrhythmic firing. Simulations and analysis of an ion-channel mathematical model quantitatively reproduced these effects, showing how the macroscopic geometry affected the single-cell electrophysiology via the influence of gap junction-mediated electrical coupling. The results urge caution in translating observations of arrhythmia in vitro to predictions in vivo where the tissue geometry is very different. Stephanie will also highlight related results about the influence of domain geometry on period-doubling instabilities in two-dimensional spiral wave patterns.
If you would like to meet with Stephanie, please contact Scott McCalla at firstname.lastname@example.org