PhD Defense by Hannah McKinney
- Friday, March 27, 2020 from 12:00pm to 1:00pm
- WebEx: https://montana.webex.com/meet/m72k892
Hannah McKinney, PhD candidate in Neuroscience will present her dissertation defense "A fruit fly model of dual neurotransmission circuitry: Mechanisms and behavioral effects of multiple neurotransmitter signaling" on WebEx on March 27 at 12 p.m.
Please join her via WebEx at https://montana.webex.com/meet/m72k892
ABSTRACT: Dual transmission, or the ability of a neuron to signal with more than one neurotransmitter, is now a well-established phenomenon in the field of neuroscience. However, many questions about this type of signaling process still remain with regards to its mechanisms and its impacts on neural circuitry and organism behavior. In the fruit fly Drosophila melanogaster, a particular subset of neurons important for the behaviors of courtship and aggression has been demonstrated to signal using both the neuromodulator octopamine and the excitatory neurotransmitter glutamate. Behavioral experiments indicate a separate role for glutamate in octopamine-glutamate neurons (OGNs). Examination of octopamine and glutamate receptor neuronal expression reveals potential presynaptic autoreception in these neurons, which may serve to modulate the release of glutamate and/or octopamine from OGNs. Understanding the mechanisms of dual transmission circuitry in fruit flies provides crucial insights into its role in governing the behavior of more complex organisms, including humans.
- Department of Microbiology & Immunology