How to describe, analyze and interrogate dynamics of gene regulatory networks
- Thursday, October 22, 2020 from 3:00pm to 4:00pm
- Webex Meeting number: 120 556 7048 Password: applied
We first describe mathematical foundation of DSGRN (Dynamic Signatures Generated by Regulatory Networks), an approach that provides a queryable description of global dynamics of a network over its entire parameter space. We describe a connection to Boolean network models that allows us to view DSGRN as a platform for bifurcation theory of Boolean maps.
We describe several applications. We show how to use DSGRN to
(1) design a network that performs a biological function;
(2) diagnose why a synthetic network failed, and
(3) delineate dynamics of network that governs epithelial-mesenchymal transition, which allows cells to escape confinement of a tissue and migrate.
- Department of Mathematical Sciences