CBE Virtual Seminar: Mechanisms, regulation, and consequences of Vibrio cholerae biofilm formation

Dr. Fitnat Yildiz is a professor of microbiology & environmental toxicology at the University of California Santa Cruz. She earned her Ph.D. from Indiana University and completed postdoctoral studies at Carnegie Institution of Washington and Stanford University Medical School. She was a recipient of the Ellison Medical foundation New Scholar Award in Global Infectious Disease and is a Fellow of the American Academy of Microbiology. Her research focuses on understanding molecular mechanisms of biofilm formation, c-di-GMP signaling, and environmental stress response. 

Presentation Abstract: V. cholerae’s stability to form biofilms, extracellular matrix-enclosed, surface-associated microbial communities, is crucial for its survival in aquatic habitats between epidemics and is advantageous for host-to-host transmission during epidemics. In this presentation, Dr. Yildiz will describe V. cholerae biofilm matrix components and their role in the biofilm matrix assembly. All aspects of biofilm formation, i.e., cell-surface interactions and biofilm matrix production, are exquisitely controlled by the nucleotide-based intracellular signaling molecule cyclic di-guanosine monophosphate (c-di-GMP). She'll describe how c-di-GMP governs motile-to-biofilm-life transition and biofilm matrix production. Finally, Dr. Yildiz will discuss the mechanism of biofilm-mediated hyperinfectivity.

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