Department of Chemistry and Biochemistry Seminar
- Friday, October 29, 2021 at 3:10pm
Prof. Rock Mancini (Washington State University) will present “Smart Immunomodulators for Controlling Toll-Like Receptor and Macrophage-Inducible C-Type Lectin Receptor Signaling”
Abstract: Immunomodulators span a highly diverse chemical space with significant potential to enhance immunotherapeutic and vaccine efficacy alike. However, further implementation of synthetic immunomodulators in medicine requires meticulous control over biodistribution and pharmacokinetics to prevent side-effects, such as systemic inflammatory toxicity. To address this drug delivery problem, we synthetically impart stimuli-responsive characteristics to immunomodulators. To-date we have created stimuli-responsive “smart” immunomodulators that activate Toll-Like Receptors (TLRs) or Macrophage-Inducible C-Type Lectin (MINCLE) receptors on innate immune cells in response to unique stimuli present in target environments, such as solid tumors or vaccine adjuvant depots. This presentation will highlight two types of smart immunomodulators developed by our lab. First, we will discuss imidazoquinoline glycosides, a new class of TLR 7/8 agonist immunotherapeutic that exploits the aberrant carbohydrate metabolism of many chemo-resistant cancers. Second, thermoresponsive MINCLE agonists and their adaptogenic properties linking pyrexia to homeostasis will be discussed in the context of their potential use as vaccine adjuvants.
Byker Auditorium or by WEBEX INVITE
Host: Prof. Matt Cook
Masks required in the Byker Auditorium
- Department of Chemistry and Biochemistry