Concentration:Bigalke

Sleep and Autonomic Physiology

Degrees Held:

B.S., Physiology, Michigan State University, 2017

M.S., Kinesiology, Michigan Technological University, 2019

Email:

[email protected]

Advisor:

Jason R. Carter, PhD

Research Interests:

Sleep and autonomic function, with a specific interest in the impact of insomnia on cardiovascular control.

Function of the orexin system in the development of hypertension.

Intersection between emotional regulation, sleep pathology, and autonomic dysfunction.

Peer-Reviewed Journal Publications:

Bigalke JA, Carter JR. Sympathetic Neural Control in Humans with Anxiety-Related Disorders. Comp Physiol. (Accepted).

*Bigalke JA, Greenlund IM, Nicevski JR, Smoot CA, Oosterhoff B, John-Henderson NA, Carter JR. Blunted Heart Rate Recovery to Spontaneous Nocturnal Arousals in Short Sleeping Adults. Am J Physiol Heart Circ Physiol 321 (3): H558-H566 (2021). *American Physiological Society Select Article – October 2021

Fan Y, Jiang E, Gao H, Bigalke JA, Chen B, Yu C, Chen QH, Shan Z. Activation of Orexin System Stimulates CaMKII Expression. Front Physiol. 12: 698185 (2021).

Greenlund IM, Bigalke JA, Tikkanen AL, Durocher JJ, Smoot CA, Carter JR. Evening Binge Alcohol Disrupts Cardiovagal Tone and Baroreflex Function During Polysomnographic Sleep. SLEEP. (In Press).

Bigalke JA, Greenlund IM, Nicevski JR, Carter JR. Effect of Evening Blue Light Blocking on Subjective and Objective Sleep in Healthy Adults: A Randomized Control Trial. Sleep Health 7 (4): 485-490 (2021).

Gao H, Bigalke JA, Fan Y, Jiang E, Chen B, Chen Q, Shan Z. TNFα Triggers an Augmented Inflammatory Response in Brain Neurons from Dahl Salt Sensitive Rats Compared with Normal Sprague Dawley Rats. Cell Mol Neurobiol. (In Press).

Bigalke JA, Gao H, Chen QH, Shan Z. Activation of Orexin 1 Receptors in the Paraventricular Nucleus Contributes to the Development of DOCA-Salt Hypertension Through Regulation of Vasopressin. Front Physiol 12: 641331 (2021).

Greenlund IM, Cunningham HA, Tikkanen AL, Bigalke JA, Smoot CA, Durocher JJ, Carter JR. Morning Sympathetic Activity after Evening Binge Alcohol Consumption. Am J Physiol Heart Circ Physiol320 (1): H305-H315 (2021).

Greenlund IM, Bigalke JA, Carter JR. Commentaries on Point:Counterpoint: Investigators should/should not control for menstrual cycle phase when performing studies of vascular control. J Appl Physiol 129: 1122-1135 (2020).

Bigalke JA, Greenlund IM, and Carter JR. Sex Differences in Self-Report Anxiety and Sleep Quality During COVID-19 Stay-At-Home Orders. Biology of Sex Differences 11 (1): 56 (2020).

Published Conference Abstracts:

Bigalke JA, Greenlund IM, Tikkanen AL, Nicevski JR, Medalie L, Mokhlesi B, Carter JR. Insomnia Symptom Severity is Associated with Increased Muscle Sympathetic Nerve Activity in Chronic Insomnia. American Autonomic Society. 2021.

Greenlund IM, Bigalke JA, Tikkanen AL, Nicevski JR, Smoot CA, Durocher JJ, Carter JR. Morning Cardiovascular Reactivity After Evening Binge Alcohol Consumption: Sex Differences. American Autonomic Society. 2021.

Nicevski JR, Kerkering EM, Bigalke JA, Greenlund IM, Tikkanen AL, Carter JR. Actigraphy-Based Total Sleep Time is Not Associated with Muscle Sympathetic Nerve Activity in Healthy Adults. American Autonomic Society. 2021.

Bigalke JA, Greenlund IM, Nicevski JR, John-Henderson NA, and Carter JR. Differential Impact of Sleep Duration on Nocturnal Blood Pressure Dipping Between Men and Women. SLEEP. 2021

Greenlund IM, Bigalke JA, Tikkanen AL, Nicevski JR, Smoot CA, Carter JR. Sex Differences in Slow Wave Sleep Following Evening Binge Alcohol Consumption. SLEEP. 2021.

Greenlund IM, Bigalke JA, Tikkanen AL, Smoot CA, Durocher JJ, Carter JR. Evening Binge Alcohol Disrupts Cardiovagal Tone and Baroreflex Function During Polysomnographic Sleep Stages. Federation of American Societies for Experimental Biology35: 1. 2021

Bigalke JA, Greenlund IM, Nicevski JR, John-Henderson NA, and Carter JR. Association Between Short Sleep Duration and Increased Cardiovascular Response to Nocturnal Arousal. Federation of American Societies for Experimental Biology 35: 1. 2021

Bigalke JA, Fonkoue IT, Greenlund IM, and Carter JR. Trait Anxiety and Blood Pressure Reactivity to Mental Stress. Federation of American Societies for Experimental Biology34: 1. 2020

Gao H, Bigalke JA, Bloch C, Chen Q, Chen B, and Shan Z. Plasma Orexin A Level is Increased in Salt-Sensitive Hypertension. Federation of American Societies for Experimental Biology34: 1. 2020

Bigalke JA, Chen Q, and Shan Z. Orexin Function in the DOCA-Salt Rat Model. Federation of American Societies for Experimental Biology33: 835.5. 2019

Alharbi WF, Bigalke JA, Chen Q, and Shan Z. Orexin A Receptor 1 (OX1R) Activation Increases Expression of Cytokines in PC12 Cells. Federation of American Societies for Experimental Biology33: 692.10. 2019

Bigalke JA, Jiang EJ, Hahka TM, Chen Q, and Shan Z. PVN Orexin Receptor 1 Knockdown Effect on Metabolism and Fluid Homeostasis. Federation of American Societies for Experimental Biology33: 835.5. 2018

 

Presentation Experience:

SLEEP Conference – Online Format

Poster Presentation
2021
Differential Impact of Sleep Duration on Nocturnal Blood Pressure Dipping Between Men and Women

Experimental Biology Conference – Online Format

Poster Presentation
2021
Association Between Short Sleep Duration and Increased Cardiovascular Response to Nocturnal Arousal

Michigan Physiological Society – Mt. Pleasant, MI

Oral Presentation
2019
Orexin Regulation of AVP in the DOCA-Salt Rat Model

Experimental Biology Conference - Orlando, FL

Poster Presentation
2019
Orexin Function in the DOCA-Salt Rat Model

MTU Graduate Research Colloquium – Houghton, MI

Oral Presentation
2019
Orexin Function in the DOCA-Salt Rat Model

MTU Kinesiology and Integrative Physiology Seminar Series – Houghton, MI

Poster Presentation
2019
The Role of Orexin in the DOCA Rat Model                                                  

Michigan Space Grant Consortium – Ann Arbor, MI

Poster Presentation
2018
The Apollo Number and Suit Dynamics                                                           

Michigan Physiological Society – Houghton, MI

Oral Presentation / Co-Chair for session
2018
PVN Orexin Receptor 1 Knockdown Effect on Metabolism and Fluid Homeostasis

Gull Lake Hypertension Workshop - Gull Lake, MI

Oral Presentation / Co-Chair for session
2018
Increased PVN Orexin Signaling Contributes to Sympathoexcitation in Salt-Sensitive Hypertension

Experimental Biology Conference - San Diego, CA

Poster Presentation
2018
PVN Orexin Receptor 1 Knockdown Effect on Metabolism and Fluid Homeostasis

Life Science and Technology Institute Research Forum - Houghton, MI

Poster Presentation
2018
PVN Orexin Receptor 1 Knockdown Effect on Metabolism and Fluid Homeostasis

Funding Awards:

2019-2020: J. Bigalke (PI): “Effect of Blue Light Exposure on Sleep Efficiency in Space” Michigan Space Grant Consortium Fellowship. $5,000 (total).

2018-2019: J. Bigalke (PI): “Orexin Control of Arginine Vasopressin in DOCA-Salt Hypertension” Songer Research Award for Human Health Research. $6,000 (total).

 

Academic Awards:

Michigan Physiological Society Best Oral Presentation Award    

2019
1st Place
Central Michigan University

Graduate Student Government Colloquium Best Oral Presentation Award     

2019
3rd Place
Michigan Technological University

Dean’s Outstanding Scholarship Award      

2019
Michigan Technological University

 

Professional Membership:

American Autonomic Society

Graduate Student Member
2021–Present           

Sleep Research Society

Graduate Student Member
2020–Present 

American Physiological Society

Graduate Student Member
2019–Present 

Michigan Physiological Society

Graduate Student Member
2018–2020